Mathematical evaluation of 24-hour blood-pressure variability in young, middle-aged and elderly hypertensive patients.

Tochikubo, Osamu; Miyazaki, Nobuyuki; Yamada, Yutaka; Fukuoka, Masakazu; Kaneko, Yoshihiro

doi:10.1253/jcj.51.1123

Cited by 17 publications

(10 citation statements)

References 17 publications

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“…Changes in heart rate (HR) and blood pressure over a 24-h period take place not in a disorderly fashion, but are influenced by several conditions (44)(45)(46)(47)(48). For example, during nocturnal sleep, HR and BP in normotensive and hypertensive subjects (28,45,46).…”

Section: Methods O F Calculating Positive Load and Negative Load Compomentioning

confidence: 99%

Circadian Variation of Hemodynamics and Baroreflex Functions in Patients with Essential Hypertension.

et al. 1997

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It is well known that cardiovascular accidents such as myocardial infarction frequently occur in the morning, but their triggering mechanisms are not clear. The present study investigated circadian variations of hemodynamics and baroreflex functions. Twenty-three patients with essential hypertension were studied. Direct blood pressure (BP) and ECG were recorded by telemeter over 24 h, and then computeranalyzed. The pulse-contour method was used to measure cardiac output (CO) and total peripheral vascular resistance (TPR). The ratio of low to high frequency components (LF/HF) of the RR-interval on ECG was calculated by power spectral analysis. The baroreflex sensitivity index (BR!) was measured on the basis of the ratio d RR/LI Ps (zl Ps= spontaneous decrease in systolic BP, zl RR = change in RR). Furthermore, 24-h BP changes were transformed algebraically into positive load component (PC) and negative load component (NC) by using a Windkessel model. The circadian variation of hematocrit (Ht) was also measured. The least squares method was used to determine the time at which the maximum and minimum value of each measurement occurred. Whereas the maximum values for BP and CO occurred in the evening (18:30, 17:00), the maximum values for TPR and LF/HF occurred between 06:30 and 08:00, and the minimum value for BRI occurred at 08:00. PC significantly correlated with Ps, heart rate, and CO (r=0.81, 0.92, 0.67), and NC significantly correlated with BRI and LFIHF (r=0.71, 0.64). PC (related to cardiovascular function) reached a maximum and NC (related to baroreflex function) reached a minimum in the late morning (11:00). Ht was highest immediately after the subjects got out of bed. These hemodynamic imbalances may negatively influence coronary blood flow in the morning. (Hypertens Res 1997; 20: 157-166)

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Section: Methods O F Calculating Positive Load and Negative Load Compomentioning

confidence: 99%

Circadian Variation of Hemodynamics and Baroreflex Functions in Patients with Essential Hypertension.

et al. 1997

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“…Mean systolic blood pressure (mSBP) and diastolic blood pressure (mDBP), and the coefficient of variability of systolic blood pressure (cvSBP) and diastolic blood pressure (cvDBP) were calculated. The BPV was calculated by the following formula which correlated to each blood pressure value [14,15]: N = total number of measurements, n = number of sequential measurements.…”

Section: Blood Pressure Variabilitymentioning

confidence: 99%

The Effect of Baroreflex Function on Blood Pressure Variability

Wei¹,

Fang²,

Ren³

et al. 2013

IJCM

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Objective: The aim of this study was to assess the relationship of blood pressure variability (BPV) and heart rate variability (HRV) to investigate the effect of baroreflex function on blood pressure variability. Methods: This study consisted of 111 subjects, including 32 normotensives and 79 hypertensives. All the subjects were given two concurrent tests: 24-hour Holter ECG and ambulatory blood pressure monitoring. According to standard deviation of normal-to-normal sinus RR intervals (SDNN) derived from the Holter ECG, the hypertensives were divided into two groups: an HRV normal group with SDNN > 100 ms and an HRV abnormal group with SDNN < 100 ms. HRV analysis used the time domain measure SDNN and two frequency domain analyses using low-frequency and high-frequency power. BPV analysis involved a formula correlated to each blood pressure value. Results: BPV was significantly higher in the HRV abnormal group compared with the HRV normal group in the hypertensives (0.018 ± 0.0033 vs 0.014 ± 0.0032, P < 0.05). In the HRV abnormal group, BPV value of the older hypertensive participants was higher than the younger participants (0.019 ± 0.0024 vs 0.017 ± 0.0037, P = 0.048). BPV and HRV were correlated in the younger hypertensives (r = −0.314, P < 0.05) and older hypertensives (r = −0.692, P < 0.001). Conclusions: Baroreflex function had effect on BPV. Factors like aging could cause damage to the baroreflex sensitivity, which in turn had influence on BPV. There may be benefits in restoration of baroreflex function to reduce BPV, especially in hypertensive patients.

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“…39 BP0 is more closely related to the severity of hypertension-related organ damage than other 24-h BP parameters. [39][40][41][42][43] The frequent development of isolated diastolic hypertension in young adults is consistent with an abnormal PVR. 44,45 Elevated DBP at any age is a marker of increased PVR.…”

Section: Clinical Application Of the Fop Measurementmentioning

confidence: 81%

New Finger-Occlusion Plethysmograph for Estimating Peripheral Blood Flow and Vascular Resistance

Kura

Fujikawa

Tochikubo

2008

Circ J

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Mathematical evaluation of 24-hour blood-pressure variability in young, middle-aged and elderly hypertensive patients.

Cited by 17 publications

References 17 publications

Circadian Variation of Hemodynamics and Baroreflex Functions in Patients with Essential Hypertension.

Circadian Variation of Hemodynamics and Baroreflex Functions in Patients with Essential Hypertension.

The Effect of Baroreflex Function on Blood Pressure Variability

New Finger-Occlusion Plethysmograph for Estimating Peripheral Blood Flow and Vascular Resistance

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