CT has recently been used in mass screening for lung cancer. Small cancers have been identified but the growth characteristics of these lesions are not fully understood. We identified 82 primary cancers in our 3-year mass CT screening programme, of which 61 were examined in the present study. The volume doubling time (VDT) was calculated based on the exponential model using successive annual CT images or follow-up CT images. All cases were also examined in the hospital by high resolution CT (HRCT). Lesions were divided into three types based on HRCT characteristics: type G (n = 19), ground glass opacity (GGO); type GS (n = 19), focal GGO with a solid central component; and type S (n = 23), solid nodule. 18 (95%) lesions of type G, 18 (95%) of type GS and 7 (30%) of type S were invisible on conventional chest radiographs. The mean size of the tumour was 10 mm, 11 mm and 16 mm for type G, type GS and type S, respectively. Most tumours (80%) were adenocarcinomas; 78% of these were GGO (type G and GS). Mean VDT values were 813 days, 457 days and 149 days for type G, type GS and type S, respectively; these are significantly different from each other (p < 0.05). Our results show that annual mass screening CT for 3 successive years resulted in the identification of a large number of slowly growing adenocarcinomas that were not visible on chest radiographs.
The different adaptive problems faced by men and women over evolutionary history led evolutionary psychologists to hypothesize and discover sex differences in jealousy as a function of infidelity type. An alternative hypothesis proposes that beliefs about the conditional probabilities of sexual and emotional infidelity account for these sex differences. Four studies tested these hypotheses. Study 1 tested the hypotheses in an American sample (N = 1,122) by rendering the types of infidelity mutually exclusive. Study 2 tested the hypotheses in an American sample (N = 234) by asking participants to identify which aspect of infidelity was more upsetting when both forms occurred, and by using regression to identify the unique contributions of sex and beliefs. Study 3 replicated Study 2 in a Korean sample ( N = 190). Study 4 replicated Study 2 in a Japanese sample (N = 316). Across the studies, the evolutionary hypothesis, but not the belief hypothesis, accounted for sex differences in jealousy when the types of infidelity are rendered mutually exclusive; sex differences in which aspect of infidelity is more upsetting when both occur; significant variance attributable to sex, after controlling for beliefs; sex-differentiated patterns of beliefs; and the cross-cultural prevalence of all these sex differences.
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