Introduction: Acne is the most common skin disorder that affects nearly 80% of people in periods of life. Patients with acne often experience depression and anxiety and low selfesteem and generally experience lower quality of life. Therefore, the aim of this study was to evaluate and compare the quality of life in patients with acne vulgaris before and after treatment. Materials and Methods: In this clinical trial, patients with acne referred to the skin clinic were examined. Patients were examined by a clinician and information was collected using a standard questionnaire for determining the severity of acne. After confirming the incidence of acne based on the severity of the disease, they were divided into three groups: mild, moderate and severe. Then, quality of life and self-esteem of patients were assessed using standard questionnaires and then each group received standard pharmaceutical treatment. After the end of the treatment period, the quality of life and self-esteem of patients were re-evaluated. Finally, statistical analysis was performed using SPSS software via t-test and chi square methods. Results: A total of 90 patients were enrolled (30 males and 60 females) with an average age of 26.9 ± 6.1. The results of the study showed that the level of quality of life in the mild, moderate and severe acne group after treatment was significantly higher than the pre-treatment. Also, the level of self-esteem in the mild, moderate and severe groups of the treatment group was significantly higher than the pre-treatment. Conclusion:The results suggest that treatments have significantly improved the clinical symptoms of acne and increased quality of life and self-esteem in patients. This indicates the importance of acne treatment to improve quality of life and increase self-esteem.