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BackgroundThe mouse represents an important model system to study the host response to influenza A infections and to evaluate new prevention or treatment strategies. We and others reported that the susceptibility to influenza A virus infections strongly varies among different inbred mouse strains. In particular, DBA/2J mice are highly susceptible to several influenza A subtypes, including human isolates and exhibit severe symptoms after infection with clinical isolates.FindingsUpon intra-muscular immunization with live H1N1 influenza A virus (mouse-adapted PR8M, and 2009 pandemic human HA04), DBA/2J mice mounted virus-specific IgG responses and were protected against a subsequent lethal challenge. The immune response and rescue from death after immunization in DBA/2J was similar to those observed for C57BL/6J mice.ConclusionsDBA/2J mice represent a suitable mouse model to evaluate virulence and pathogenicity as well as immunization regimes against existing and newly emerging human influenza strains without the need for prior adaptation of the virus to the mouse.

Das Reduktionsverhalten durch Auffällen hergestellter NiOAl2O3/SiO2‐Katalysatoren wird durch die Phasenzusammensetzung (amorphe Nickelschicht‐und alumoschichtsilicate, Nickelspinelle, Nickeloxid) und durch die Unterschiede in der Zusammensetzung zwischen Volumen und Oberfläche bestimmt. TPR‐Messungen, Bestimmungen des Reduktionsgrades und der Nickelpartikelgrößen durch statische magnetische Messungen zeigten, daß bei geringen Al2O3‐Gehalten die Reduzierbarkeit der NiOAl2O3/SiO2‐Katalysatoren erhöht und die Nickeldispersität vermindert wird. Die Abnahme der Reduzierbarkeit bei Al2O3‐Gehalten >5 Mol‐% wird durch die Bildung von Nickelspinellen und durch die Abnahme der NiII‐Ionenoberflächenkonzentration verursacht.

SUMMARY%Methyl -6-[3-( t r i f 1 uoromethyl ) phenyl 1-1,2,4-triazolo [4,3-b] p y r i d a z i n e ($), c u r r e n t l y being evaluated as a p o t e n t i a l anxio- l y t i c agent was synthesized, l a b e l e d w i t h carbon-14 i n the 3-p o s i t i o n o f t h e t r i a z o l o nucleus. i n 67% radiochemical y i e l d w i t h s p e c i f i c a c t i v i t y o f 13.5mCi/mmol and r a d i o p u r i t y of g r e a t e r than 99%. The carbon-13 l a b e l e d compound was a l s o synthesized f o r absorption and metabolism studies.

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