Despite the high level of movement of people and goods among Kazakhstan, Kyrgyzstan, Tajikistan, and Uzbekistan, laws governing cross-border movements neither accord preferential treatment to residents of bordering regions nor provide institutional structures that would foster cross-border cooperation. Such laws constitute barriers to deepening cross-border cooperation. Moreover, decisions concerning crossborder movements of people, goods, and services are controlled by central governments: local governments cannot act on their own to cooperate with foreign entities. Consequently, and given the various degrees of decentralization in decision-making, local trans-border initiatives face serious administrative barriers. This article argues that there is the large potential for growth that lies untapped due to the obstacles to cross-border development activities and proposes adapting the institutional concept of regional cooperation between bordering regions in neighboring countries, modeled after Euroregions, to countries in Central Asian. Their advantage would lie in establishing structures for cooperation in areas ranging from commerce to culture, environment, tourism, and education.