The leaves of the Itchy leaves plant (Laportea decumana (Roxb.) Wedd) are considered very effective in Papuan traditional medicine as a natural anti-pain (analgesic) treatment. This study aimed to determine the quality and effectiveness of the analgesic patches made from the Itchy leaves plant. Three formulas were used with the composition of the simplicia in the formula; FI 0.38% (w/v), FII 1.11% (w/v), and FIII 1.80% (w/v). The patch quality evaluation included organoleptic qualities, weight variation, folding endurance, thickness, drying loss, percent elongation, and an irritation test. In the analgesic effect test, the wriggling method was used on mice, and induced intraperitoneally with acetic acid. The mice were divided into five groups: negative control, positive control, and three groups receiving doses using patches FI, FII, and FIII. The observation of wriggling was calculated in 5-min intervals for 1 h. Data were analyzed statistically using the one-way ANOVA test and the least significant difference (LSD) test with a significant level of 5% (p≤0.05). The results showed that patches had an imperfect round shape, distinctive odor, green color, consistent weight, consistent thickness, flexibility, elasticity, and produced a little irritation, which was not harmful. The results of the statistical analysis of FI, FII, and FIII of the Itchy leaf patch (Laportea decumana (Roxb.) Wedd) showed significant differences in analgesic effects. The analgesic effect test results showed that patch FII with a crude drug composition of 1.11% (w/w) had the best reduction in wriggling responses in mice, with a protective power of 68.69%.
