Motivation: Deep metagenomic sequencing of biological samples has the potential to recover otherwise difficult-to-detect microorganisms and accurately characterize biological samples with limited prior knowledge of sample contents. Existing metagenomic taxonomic classification algorithms, however, do not scale well to analyze large metagenomic datasets, and balancing classification accuracy with computational efficiency presents a fundamental challenge.Results: A method is presented to shift computational costs to an off-line computation by creating a taxonomy/genome index that supports scalable metagenomic classification. Scalable performance is demonstrated on real and simulated data to show accurate classification in the presence of novel organisms on samples that include viruses, prokaryotes, fungi and protists. Taxonomic classification of the previously published 150 giga-base Tyrolean Iceman dataset was found to take <20 h on a single node 40 core large memory machine and provide new insights on the metagenomic contents of the sample.Availability: Software was implemented in C++ and is freely available at http://sourceforge.net/projects/lmatContact: allen99@llnl.govSupplementary information: Supplementary data are available at Bioinformatics online.

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Abstract-Processing large graphs is becoming increasingly important for many domains such as social networks, bioinformatics, etc. Unfortunately, many algorithms and implementations do not scale with increasing graph sizes. As a result, researchers have attempted to meet the growing data demands using parallel and external memory techniques.We present a novel asynchronous approach to compute Breadth-First-Search (BFS), Single-Source-Shortest-Paths, and Connected Components for large graphs in shared memory. Our highly parallel asynchronous approach hides data latency due to both poor locality and delays in the underlying graph data storage. We present an experimental study applying our technique to both In-Memory and Semi-External Memory graphs utilizing multi-core processors and solid-state memory devices. Our experiments using synthetic and real-world datasets show that our asynchronous approach is able to overcome data latencies and provide significant speedup over alternative approaches. For example, on billion vertex graphs our asynchronous BFS scales up to 14x on 16-cores.