The preparation and sale of street foods is booming in African cities in general and especially in N'Djamena. However, the hygienic failures observed during this activity constitute a source of contamination of these foods. The objective of this work is to determine the different serotypes of Salmonella isolated from food sold in the streets of N'Djamena in Chad and to test their sensitivity antibiotics. In total, 447 samples from 12 different types of food were collected and analyzed using standard food microbiology methods. The disk diffusion method was used to test the antibiotic susceptibility of Salmonella strains detected. The serotyping of the 5 strains of Salmonella allowed us to identify 3 serotypes namely Salmonella Mbandaka, Salmonella Idikan and Salmonella Anatum. The susceptibility profiles of the strains to antibiotics were varied. Resistance were observed with the antibiotics Amoxicillin + Clavulanic acid, Cefotaxime and Nalidixic acid. The most active antibiotics were Cefoxitne, Ciprofloxacin, Aztreonam, Imipenem and Choramphenicol with a rate of 100% sensitivity. However, the resistance of these strains to certain antibiotics is a real public health problem that calls out to food safety.