Background: Patients admitted to intensive care units may be needed intravascular catheters for several purposes, but this device may be present without indication. Central or peripheral intravenous catheters are associated with local and systematic complications. Bloodstream infection event is categorized into bloodstream infection from the central line and non-central line. Aims: To explore the impact of the implementation of the I-DECIDED tool on bloodstream infection events in the ICU. Research design: A quasi-investigational research design was utilized. Setting: Intensive care units of Al-Behera hospitals in Egypt were included. Population: The total sample size included 120 patients, where the newly admitted adults aged ≥18 years are patients who are attached to the intravenous catheters. The data gathering: Two tools were developed, where the first one was the patient clinical assessment consisting of 4 parts and the second one was the clinical patient outcomes assessment. Results: Routine group had an increase in temperature than the intervention group. The routine group was a significantly high phlebitis score than the intervention one (p< 0.001). The routine group also had a higher Pitt score of 10.20±4.74 than the intervention one which was 7.95±5.52 with a significant among them (p= 0.001). A significant difference between routine and intervention groups in primary bloodstream infection, noncentral line infection, and central line infection was noted, orderly (p1=0.003; p2=0.001; and p3=0.014). Conclusion: I-DECIDED is an innovation tool used to improve performance and modify nurses' behavioral changes and advocate for patient safety. Recommendation: Using I-DECIDED to care for peripheral venous catheters and help nurses to decide on early removal and detection of complications.