No abstract

There have not been yet enough studies about effects of beta glucan and gliclazide on oxidative stress created by streptozotocin in the brain and sciatic nerve of diabetic rats. The aim of this paper was to investigate the antioxidant effects of gliclazide and beta glucan on oxidative stress and lipid peroxidation created by streptozotosin in brain and sciatic nerve. Total of 42 rats were divided into 6 groups including control, diabetic untreated (DM) (only STZ, diabetic), STZ (DM) + beta glucan, STZ (DM) + gliclazide, only beta glucan treated (no diabetic), and only gliclazide treated (no diabetic). The brain and sciatic nerve tissue samples were analyzed for malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON-1) levels. We found a significant increase in MDA, TOS, and OSI along with a reduction in TAS level, catalase, and PON-1 activities in brain and sciatic nerve of streptozotocin-induced diabetic rats. Also, this study shows that in terms of these parameters both gliclazide and beta glucan have a neuroprotective effect on the brain and sciatic nerve of the streptozotocin-induced diabetic rat. Our conclusion was that gliclazide and beta glucan have antioxidant effects on the brain and sciatic nerve of the streptozotocin-induced diabetic rat.

The parents of children with EN seem to experience increased levels of anxiety. Their desire to continue the marital relationship, the overall quality of their marital relationship and their comfort as a family may also be negatively affected by having a child with EN.

BMI and plasma leptin levels both were correlated with the severity of pancreatitis. Leptin levels showed better area under the curve, sensitivity and specificity values compared to BMI in prediction of pancreatic necrosis.Nesfatin-1 and ghrelin levels were not found to be predictors of the severity of disease.

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. It stems from defects, which are formed in insulin secretion, insulin effect or both caused by interactions of genetics, environmental factors and life style changes. As well as being a very serious and progressive disease, we face it as a major health problem for both individuals and society for it adversely affects the mortality and morbidity by causing chronic and acute complications in case of lack of control.Maximum effort should be made in order to prevent diabetes in all sections of society. Family medicine doctors have the greatest part in this regard for their unique roles in primary care. Therefore, primary care health personnel should evaluate the patients in terms of diabetes risk factors, take the preventive measures against development of diabetes and do diabetes screening for required individuals. They should follow up the treatments and controls of the patients having diabetes in order to avoid complications. Since prevention and treatment requires a multi-disciplinary approach, they should to refer patients to nephrology, ophthalmology, cardiology etc. departments. To this end, diabetes and approach to diabetic patients have been examined in this article. J Clin Exp Invest 2013; 4 (4): 562-567