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The biocompatibility of orthopaedic implants and their effects on fracture healing have key roles for success. In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan (Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. A total of 60 adult male Wistar rats weighing 300-500 g were used in the study. The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated). Biocomposite (HA/h-BN/Cs/Ct1) coated and uncoated stainless-steel implants were used as intramedullary pins. Groups A and B were divided into subgroups of A1 and B1 (15th day), A2 and B2 (30th day), A3 and B3 (45th day) according to the date of euthanasia. Clinical, radiographic, haematological, biochemical, and histopathological findings were evaluated by pairwise comparisons. The findings were consistent and similar. No statistically significant difference was found for a finding disturbing the biocompatibility. Histopathological examinations showed that coating biomaterials did not resorb over the course of 15, 30, and 45 days. It is thus revealed that the content is biocompatible. However, it has been concluded that it is necessary to increase the physical strength of the coating surface against sterilization and surgical procedures. As a result, based on the interpretations of the clinical, radiographic, haematological, biochemical, and histopathological findings, the biocompatibility of HA/h-BN/Cs/Ct1 biocomposite materials has been revealed.

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In this clinical study, effects of diazepam + ketamine HCl + sevoflurane anesthesia on vital functions and recovery duration and qualityofnine long legged buzzards were evaluated upon wing amputation. Operation was decided for long legged buzzards and heartand breathingrate, body temperature, and reflexes of long legged buzzards were evaluated before, during and after the anesthesia. Diazepam and ketamine HCl injection increased the heart rate whereas it was decreased by sevoflurane. Respiratory rate decreased upon sevoflurane application. Body temperature decreased during anesthesia. Recovery began in the 3rd minute after cessation of sevoflurane administration with return of eye reflexes and completedin the 35th minute. It was observed that although birdsrecovered from anesthesia, danger of hypothermia persisted for a long time.There was a significant difference between the respiratory and heart rates during the ketamine HCl and sevofluraneanesthesia from those in the preoperative period. However, there was no statistically significant difference between pre and post operative periods in terms of vital parameters. For the first time, effects of diazepam + ketamine HCl + sevoflurane anesthesia combination on vital parameters are evaluated in long legged buzzards in Turkey.