Stres merupakan suatu keadaan tertekan baik secara fisik maupun secara psikologis. Suatu proses yang menilai suatu peristiwa sebagai sesuatu yg mengancam, ataupun membahayakan dan individu merespon peristiwa itu pada level fisiologis, emosional, kognitif, dan perilaku. Hormon kortisol adalah hormon stres, karena hormon ini akan diproduksi lebih banyak saat tubuh mengalami stres baik fisik maupun emosional. Terapi murottal Al-Qur'an merupakan salah satu terapi non farmakologis yang dapat digunakan untuk mempercepat proses penyembuhan. Lantunan Al-Qur'an secara fisik mengandung unsur suara manusia. Suara dapat menurunkan hormon stres, mengaktifkan hormon endorfin alami, meningkatkan perasaan rileks dan mengalihkan perhatian dari rasa takut, cemas, dan tegang, memperbaiki sistem kimia tubuh. Surat Ar-Rahman merupakan surat Makiyah yang mempunyai karakter ayat pendek dan berulang sehingga dapat menimbulkan efek relaksasi bagi pendengar. Tujuan dari penelitian ini adalah Menganalisis efektifitas pemberian terapi Murottal Al Qur'an terhadap kadar hormon kortisol pada mencit yang mengalami stres. Metode penelitian ini adalah true experimental post-test only control group design. 35 mencit dibagi menjadi 5 kelompok, Kelompok K+: tidak diberi perlakuan murottal QS. Ar-Rahman dan tidak diberi paparan stresor kebisingan; Kelompok Kontrol (-) diberi paparan stresor kebisingan 21 hari dan tidak diberi perlakuan murottal QS. Ar-Rahman; P1 diberi paparan stresor kebisingan 21 hari + murottal QS. Ar-Rahman 1 jam/hari; P2 diberi paparan stresor kebisingan 21 hari + murottal QS. Ar-Rahman 2 jam/hari; P3 diberi paparan stresor kebisingan 21 hari + murottal QS. Ar-Rahman 4 jam/hari. Analisis data menggunakan Median Test didapatkan nilai p value adalah 0,032 (p< 0,05) menyatakan terdapat perbedaan yang signifikan kadar kortisol pada mencit dengan kontrol negatif, kontrol positif dan yang mendapat perlakuan 1, 2, dan 3. Kesimpulan penelitian ini adalah bahwa Terapi Murottal Al Quran dapat menurunkan kadar kortisol mencit yang dipapar stres kebisingan.

Objectives Estrogen deficiency causes various health problems in postmenopausal women, including osteoporosis. Phytoestrogen emerged as a potential alternative of estrogen with minimum side effects. The aims of this study were to analyze the metabolite profiling results of various extract of Chyrsophyllum cainito L. leaves, which contain phytoestrogen, through in silico study against 3OLS protein, an X-ray protein of ERβ, so it can predict the types of the phytoestrogen contents which have antiosteoporosis property. Methods In silico analysis was carried out for the compounds from the metabolite profiling data of C. cainito leaves from our previous study. The structure compounds from metabolite profiling results of various extract of C. cainito leaves were prepared with Avogadro 1.0.1 software, molecular docking was done using PyRx 0.8 software, and Biovia Discovery Studio Visualizer 2016 software was used to visualize the structure of compounds against 3OLS protein. The physicochemical characteristics of the compounds were analyzed using the SwissADME web tool. Results From in silico studies, it was known that there were total 11 compounds in C. cainito leaves that predicted as phytoestrogens which have ERβ agonist properties against 3OLS protein. The ERβ agonist was a compound that has parameters similar to 17β-estradiol in its interaction with 3OLS protein, which has a pharmacophore distance of 10.862 Å, and binding to amino acids His 475 and Glu 305 or Arg 346 at receptor-ligand docking simulation. Conclusions C. cainito leaves contain 11 compounds that are predicted to be phytoestrogens with ERβ agonist properties, which is responsible for antiosteoporosis activity.

<em>Osteoarthritis is a chronic disorder of synovial joints, characterized by progressive softening and disintegration of cartilage in joints. This is the most common type of arthritis in Indonesia with prevalence about 23.6 to 31.3% and generally suffered by middle age patients. Drug therapy for treating osteoarthritis is NSAIDs, supplements and corticosteroids. The increasing number of available drugs, drug users and more complex drug regimens caused  more side effect and potential drug interaction and  lead to another problem, it is Drug Related Problems. The purpose of this study was to identify potential Drug Related Problem categories of improper dosage and Adverse Drug Reactions in osteoarthritis outpatient in RSUD Jombang during 2016. This research is a non-experimental descriptive study conducted retrospectively, carried out in March 2017 at RSUD Jombang.  Research sample is 87 respondents of osteoarthritis outpatient which taken by systematic random sampling method. The data presented in percentage of improper dosage and Adverse Drug reactions potential case. The result found potential of improper dosage in respondent about 82,76% and Adverse Drug Reactions about 20,69%.</em>

Estrogen deficiency causes various health problems in postmenopausal women, including osteoporosis. Phytoestrogens are emerging as potential estrogen alternatives with minimal side effects. This study aimed to predict the antiosteoporosis activity of the compounds from 96% ethanol extract of Chyrsophyllum cainito L. leaves through in silico study on 3OLS protein, an X-ray protein of ERβ. In silico analysis was carried out on the compounds from metabolite profiling results of 96% ethanol extract of C. cainito leaves from previous studies. The structure of compounds resulting from metabolite profiling of 96% ethanol extract of C. cainito leaves was made using Avogadro 1.0.1 software, geometry optimization with Chemdraw molecular docking was carried out using PyRx 0.8 software, and Biovia Discovery Studio Visualizer 2021 software was used to visualize the structure of compounds against 3OLS proteins. The physicochemical characteristics of the compounds were analyzed using the SwissADME webtool. From the result, it was known that there were seven compounds in the leaves of C. cainito, which were suspected to be phytoestrogens that had ERβ agonist properties against 3OLS protein. It was an ERβ agonist because the compound had similar parameters to 17β-estradiol in its interaction with the 3OLS protein, which had a pharmacophore distance of about 10,862, and bound to the amino acids His 475 and Glu 305 or Arg 346. The 96% ethanol extract of C. cainito leaves contained seven compounds thought to be phytoestrogen with an ERβ agonist that handled its antiosteoporosis activity.