A newly developed nonionic amphiphile (GPGS‐1500), a diester composed of a Guerbet alcohol (2‐octyldodecan‐1‐ol), poly(ethylene glycol) 1500 (PEG 1500), and succinic acid esters, has been prepared as an effective nanomicelle‐forming species for the synthesis of tetrazoles in water at room temperature.
An economical and environmentally benign method for the synthesis of 5-substituted 1H-tetrazoles has been established. In this protocol, molten tetrabutylammonium bromide (TBAB) is used as both the solvent and catalyst. A mechanism involving the intermediacy of tetrabutylammonium azide (TBAN 3 ) is proposed.
The Synthesis of 5-Substituted 1H-Tetrazoles in Molten TetrabutylammoniumBromide. -Use of molten Bu 4NBr allows to carry out the reaction without any additional catalyst or organic solvent. The reaction protocol is not applicable to alkyl nitriles such as pentanenitrile and phenylacetonitrile. Aromatic nitriles substituted at the ortho-position require longer reaction times. -(XIE, A.; CAO, M.; FENG, L.; DONG*, W.; J. Chem. Res. 37 (2013) 11, 665-667,
The Synthesis of Tetrazoles in Nanometer Aqueous Micelles at Room Temperature. -A newly developed nonionic amphiphile acts as an effective nanomicelle--forming species for the synthesis of tetrazoles by 1,3-dipolar cycloadditions under aqueous conditions. -(XIE, A.; CAO, M.; LIU, Y.; FENG, L.; HU, X.; DONG*, W.; Eur. J. Org. Chem. 2014, 2, 436-441, http://dx.
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