Objectives: To investigate the prevalence and influencing factors of stress urinary incontinence (SUI) within 6-8 weeks postpartum in Jiangsu Province. Material and methods:We designed a multi-center cross-sectional study involving seven hospitals in Jiangsu province, and enrolled women who underwent postpartum examination at 6-8 weeks in these hospitals between July 2019 and June 2021. According to the presence or absence of SUI, the enrolled patients were divided into two groups: the SUI group and the non-SUI group, respectively. We assessed the general health status, noted the details of delivery, and checked the pelvic floor electromyographic parameters of the postpartum women in both groups.Results: Among 6,302 cases of postpartum women in Jiangsu province, there were 1,579 cases of SUI, with a prevalence of 25.06%. The prevalence of SUI increased significantly with age, BMI, increasing parity, coexisting constipation, organ prolapse, and diastasis recti abdominis. Compared to the non-SUI group, the SUI group had a lower mean value of the pre-baseline rest phase, shorter rise and fall times of fast muscle contractions, and a lower mean value of the endurance contraction phase. Multiple regression analysis revealed associations with weight (especially overweight and obesity), coexisting organ prolapse, constipation, parity, gestational week of delivery, mode of delivery, and mean value of endurance contraction phase. Conclusions:The prevalence of postpartum stress urinary incontinence in Jiangsu Province was 25.06%, and was linked to being overweight, parity > 2, coexisting organ prolapse, constipation, and a decrease in the mean value of the endurance contraction phase of the electromyograph. In this report, we offer a theoretical basis for the effective prevention of postpartum SUI clinically.

Background: To discuss the epidemic characteristics of syphilis during pregnancy and pregnancy outcomes with perinatal intervention in Jiangyin. Materials and Methods: A retrospective analysis of maternal syphilis cases in Jiangyin from January 2014 to December 2015. Results: Serological screening for syphilis was performed for 25,360 pregnant women cases from 2014 to 2015, and 83 cases with syphilis were identified. The positive rate was 3.27% (83/25,360), the detection rate of syphilis during pregnancy was 78.86% (20,000/25,360), and the standard treatment rate of maternal syphilis was 72.29% (60/83). The epidemiological survey results were as follows: Single-factor analysis showed that age, household registry, occupation, educational level, economic income, number of sexual partners, marital status, and if a sex partner had syphilis influenced whether a pregnant women would be infected with syphilis (p < 0.05). Logistic regression analysis showed that household registry, occupation, educational level, economic income, number of sexual partners, marital status, and whether a sex partner had a syphilis were independent factors for infection (p < 0.05). In 79 newborns whose mothers had syphilis while pregnant, six had congenital syphilis (7.59%), ten had positive titers (12.66%), and 63 (79.75%) were negative for syphilis. With treatment and follow-up, six neonates' clinical symptoms of congenital syphilis disappeared in one month. With preventive treatment, the RPR titers of all the positive newborns became negative in nine months. Conclusions: Pregnancy syphilis remained common among itinerant, low income populations with low education, and infected sexual partners in Jiangyin from 2014 to 2015. In the past two years, the city has paid attention to prevention, screening and treatment, and preliminary results show that the maternal syphilis treatment rate is high and neonatal outcomes have significantly improved. It is necessary to improve screening efforts, strengthen awareness and education, standardize treatment, and improve maternal and neonatal outcomes.

Introduction: The purpose of this study was to explore the effects and mechanisms of the long noncoding RNA (lncRNA) MIR210HG in preeclampsia development. Material and methods: We collected placental tissue from 25 patients with preeclampsia (PE) and 25 healthy pregnant women and analysed the differences in lncRNAs between the placental tissues. HTR8/SVneo cells were transfected with the MIR210HG from the samples, and we observed the effects on the biological activities of HTR8/SVneo cells in conditions of hypoxia and reoxygenation (H/R) by transwell and wound-healing assays. To clarify the mechanisms of action, we used the Western blot assay to measure the expression levels of relative proteins (MUC1-C, SMAD2, Snail, E-cadherin and N-cadherin) and cellular immunofluorescence to measure Erk protein nuclear volume. We also evaluated the correlations between expression of MIR210HG and that of miR-1226-3p, miR-1226-3p and MUC1-C by luciferase reporter assay. Results: Chip hybridisation and scans revealed that MIR210HG expression was significantly more depressed in patients with PE than in healthy pregnant women (p < 0.001). With MIR210HG overexpression, HTR8/SVneo cell invasion and migration were significantly increased in an environment of H/R plus pcDNA3.1, microRNA negative control (miR-NC) or hsa-miR-1226-3p in comparison with an environment of H/R alone (p < 0.001, respectively). Levels of miR-1226-3p were significantly suppressed in lncRNA samples subjected to H/R (p < 0.001, respectively). In addition, miR-1226-3p depressed MIR210HG activity, thereby ameliorating PE. Conclusions: By regulating miR-1226-3p/MUC1-C activity, MIR210HG can help ameliorate preeclampsia.