No abstract

Tf-DOX/DDP NPs can achieve outstanding anti-tumor activity due to the combination effect of two drugs and the active targeting ability of Tf ligands. The self-assembled polymeric nanomedicine could act as an efficient therapy method for HCC treatment.

TRIP13 is highly expressed in multiple tumors and may be used as a potential prognostic marker and therapeutic target.

SI MATERIALS AND METHODS 1 Chemical Reagents, cells, and animalsPolyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus ® , designated as Sol) was donated by the BASF Corporation (Shanghai, China). Resveratrol (Res) was provided by Dalian Meilun Biology Technology Co., Ltd. (Liaoning, China).Coumarin 6 (Cou-6) and benzalkonium chloride (BAC) were purchased from