Entity mentions embedded in longer entity mentions are referred to as nested entities. Most named entity recognition (NER) systems deal only with the flat entities and ignore the inner nested ones, which fails to capture finer-grained semantic information in underlying texts. To address this issue, we propose a novel neural model to identify nested entities by dynamically stacking flat NER layers. Each flat NER layer is based on the state-ofthe-art flat NER model that captures sequential context representation with bidirectional long short-term memory (LSTM) layer and feeds it to the cascaded CRF layer. Our model merges the output of the LSTM layer in the current flat NER layer to build new representation for detected entities and subsequently feeds them into the next flat NER layer. This allows our model to extract outer entities by taking full advantage of information encoded in their corresponding inner entities, in an inside-to-outside way. Our model dynamically stacks the flat NER layers until no outer entities are extracted. Extensive evaluation shows that our dynamic model outperforms state-ofthe-art feature-based systems on nested NER, achieving 74.7% and 72.2% on GENIA and ACE2005 datasets, respectively, in terms of Fscore.

Objective This article describes an ensembling system to automatically extract adverse drug events and drug related entities from clinical narratives, which was developed for the 2018 n2c2 Shared Task Track 2. Materials and Methods We designed a neural model to tackle both nested (entities embedded in other entities) and polysemous entities (entities annotated with multiple semantic types) based on MIMIC III discharge summaries. To better represent rare and unknown words in entities, we further tokenized the MIMIC III data set by splitting the words into finer-grained subwords. We finally combined all the models to boost the performance. Additionally, we implemented a featured-based conditional random field model and created an ensemble to combine its predictions with those of the neural model. Results Our method achieved 92.78% lenient micro F1-score, with 95.99% lenient precision, and 89.79% lenient recall, respectively. Experimental results showed that combining the predictions of either multiple models, or of a single model with different settings can improve performance. Discussion Analysis of the development set showed that our neural models can detect more informative text regions than feature-based conditional random field models. Furthermore, most entity types significantly benefit from subword representation, which also allows us to extract sparse entities, especially nested entities. Conclusion The overall results have demonstrated that the ensemble method can accurately recognize entities, including nested and polysemous entities. Additionally, our method can recognize sparse entities by reconsidering the clinical narratives at a finer-grained subword level, rather than at the word level.

BackgroundMachine learning can assist with multiple tasks during systematic reviews to facilitate the rapid retrieval of relevant references during screening and to identify and extract information relevant to the study characteristics, which include the PICO elements of patient/population, intervention, comparator, and outcomes. The latter requires techniques for identifying and categorising fragments of text, known as named entity recognition.MethodsA publicly available corpus of PICO annotations on biomedical abstracts is used to train a named entity recognition model, which is implemented as a recurrent neural network. This model is then applied to a separate collection of abstracts for references from systematic reviews within biomedical and health domains. The occurrences of words tagged in the context of specific PICO contexts are used as additional features for a relevancy classification model. Simulations of the machine learning-assisted screening are used to evaluate the work saved by the relevancy model with and without the PICO features. Chi-squared and statistical significance of positive predicted values are used to identify words that are more indicative of relevancy within PICO contexts.ResultsInclusion of PICO features improves the performance metric on 15 of the 20 collections, with substantial gains on certain systematic reviews. Examples of words whose PICO context are more precise can explain this increase.ConclusionsWords within PICO tagged segments in abstracts are predictive features for determining inclusion. Combining PICO annotation model into the relevancy classification pipeline is a promising approach. The annotations may be useful on their own to aid users in pinpointing necessary information for data extraction, or to facilitate semantic search.