One could easily argue that the most commonly studied stimulus set in experimental psychology involves English words. The study of the memory and reading of words has been central to research since Cattell (1886). Words are well-described units that provide the link between perception and meaning, and so have been critical to developments in computational modeling (e.g., McClelland & Rumelhart, 1981), neuroimaging (e.g., Petersen, Fox, Posner, Mintun, & Raichle, 1989, and conceptions of attention and automaticity (e.g., Neely, 1977;Stroop, 1935), among many other research areas.Given the importance of words as a stimulus set, one might assume that there are relatively straightforward ways to study lexical processing, and that there is a wellconstrained set of findings to which one can appeal in building models of word processing. Although there has been considerable progress in understanding how people process words, there are some clear gaps in the available literature. This paper describes the English Lexicon Project (ELP), which provides a behavioral database for over 40,000 words and nonwords that will help fill some of these gaps. The present description will focus on visual word recognition, although, as described below, the current database has relevance for other aspects of word processing, such as memory and speech production. Before describing the ELP, we will briefly describe the behavioral measures in the database, the limitations in our current knowledge, and how this database will help address these limitations. LEXICAL DECISIONS AND NAMING AS THE BEHAVIORAL TARGETSAlthough there are multiple ways to measure lexical processing (e.g., eye-fixation data, probability of iden- The English Lexicon Project is a multiuniversity effort to provide a standardized behavioral and descriptive data set for 40,481 words and 40,481 nonwords. It is available via the Internet at elexicon.wustl.edu. Data from 816 participants across six universities were collected in a lexical decision task (approximately 3400 responses per participant), and data from 444 participants were collected in a speeded naming task (approximately 2500 responses per participant). The present paper describes the motivation for this project, the methods used to collect the data, and the search engine that affords access to the behavioral measures and descriptive lexical statistics for these stimuli.

Speeded visual word naming and lexical decision performance are reported for 2428 words for young adults and healthy older adults. Hierarchical regression techniques were used to investigate the unique predictive variance of phonological features in the onsets, lexical variables (e.g., measures of consistency, frequency, familiarity, neighborhood size, and length), and semantic variables (e.g. imageahility and semantic connectivity). The influence of most variables was highly task dependent, with the results shedding light on recent empirical controversies in the available word recognition literature. Semantic-level variables accounted for unique variance in both speeded naming and lexical decision performance, level with the latter task producing the largest semantic-level effects. Discussion focuses on the utility of large-scale regression studies in providing a complementary approach to the standard factorial designs to investigate visual word recognition.

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The stability of proteins in aqueous solution is routinely enhanced by cosolvents such as glycerol. Glycerol is known to shift the native protein ensemble to more compact states. Glycerol also inhibits protein aggregation during the refolding of many proteins. However, mechanistic insight into protein stabilization and prevention of protein aggregation by glycerol is still lacking. In this study, we derive mechanisms of glycerol-induced protein stabilization by combining the thermodynamic framework of preferential interactions with molecular-level insight into solvent-protein interactions gained from molecular simulations. Contrary to the common conception that preferential hydration of proteins in polyol/water mixtures is determined by the molecular size of the polyol and the surface area of the protein, we present evidence that preferential hydration of proteins in glycerol/water mixtures mainly originates from electrostatic interactions that induce orientations of glycerol molecules at the protein surface such that glycerol is further excluded. These interactions shift the native protein toward more compact conformations. Moreover, glycerol preferentially interacts with large patches of contiguous hydrophobicity where glycerol acts as an amphiphilic interface between the hydrophobic surface and the polar solvent. Accordingly, we propose that glycerol prevents protein aggregation by inhibiting protein unfolding and by stabilizing aggregation-prone intermediates through preferential interactions with hydrophobic surface regions that favor amphiphilic interface orientations of glycerol. These mechanisms agree well with experimental data available in the literature, and we discuss the extent to which these mechanisms apply to other cosolvents, including polyols, arginine, and urea.