The present study was undertaken to test the effect of food restriction, fasting, and diabetes on the relationship between thyroid hormone receptor occupancy and two biological end points, GH production and the inhibition of TSH secretion, in thyroidectomized rats. The estimated maximal binding capacity (MBC) in diabetic (D) and fasting (F) rats and in animals limited to 25% (FR25) of the food consumption of normal (C) rats was decreased to 57%, 73%, and 76%, respectively, of C values (P < 0.01-0.001), whereas normal values were found in thyroidectomized (Tx) rats and in animals limited to 50% (FR50) of the food intake of C animals. The nuclear T3 content and T3 receptor occupancy were reduced, respectively, to 25% and 29% in Tx, 77% and 81% in FR50, 52% and 69% in FR25, 49% and 66% in F, and 36% and 64% in D rats of the corresponding C values (P < 0.05-0.001). Pituitaries from Tx, FR50, FR25, F, and D rats contained less GH than C pituitaries (0.14%, 81%, 69%, 88%, and 51%, respectively, of C pituitaries; P < 0.05-0.001). Plasma TSH was lower in FR50, FR25, F, and D rats than in C animals (78%, 57%, 52%, and 48%, respectively (P < 0.01-0.001)), and markedly increased in Tx animals. Administration of a single dose of 2, 5, or 10 micrograms T3/100 g BW to Tx C, Tx FR50, TX FR25, Tx F, and Tx D rats resulted in a similar and progressive increase in nuclear T3 in all groups, except for lower values in Tx D animals. However, receptor occupancy did not differ among the different groups at each T3 dose. This treatment resulted in a progressive increase in pituitary GH in all groups; however, in Tx FR50, Tx FR25, Tx F, and Tx D pituitaries, the GH responses to 10 micrograms T3 were only 77%, 59%, 44%, and 27%, respectively, of that in Tx C rats. (P < 0.05-0.001). Moreover, significant differences in the GH response to 10 micrograms T3 were observed among Tx FR50, Tx FR25, Tx F, and Tx D animals (P < 0.01-0.001). In addition plasma TSH levels in untreated Tx FR50, Tx FR25, Tx F, and Tx D rats were only 88%, 82%, 79%, and 72%, respectively, of that in Tx C animals (P < 0.05-0.01).(ABSTRACT TRUNCATED AT 400 WORDS)

This essay studies the translations of the Qur’ān into Romance languages in anti-Islamic treatises written by Christians in the Iberian Peninsula in the sixteenth century. It compares three such works (here called Antialcoranes or ‘anti-Qur’āns’) that contain citations of the Qur’ān in Arabic, either in Arabic script or in transliteration, or both. These include the Confusión o confutación de la secta Mahomética y del Alcorán (1515) of Juan Andrés, the Lumbre de fe contra la secta mahometana y el alcorán (1521) by Martín de Figuerola and the Confutación del alcorán y secta mahometana (1555) by Lope de Obregón. It also considers glosses found in the Latin Qur’ān made at the behest of the Italian cardinal Egidio (Giles) da Viterbo (1518). We argue that these works merit detailed study, along with more studied Latin translations, as part of a history of the translation of the Qur’ān in the early modern period.

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