Amaç: Diyabet toplumun önemli bir kısmını etkileyen ve özellikle komplikasyonlarıyla önemli bir morbidite-mortalite sebebi olan bir hastalıktır. Çalışmamızda diyabetik hastaların takipleri sırasında istenecek MPV ve hsCRP gibi tetkiklerin aslında komplikasyon gelişimi hakkında bizleri uyarıcı parametreler olarak değerlendirilebileceğine dikkat çekmek istedik. Yöntemler: Haseki Eğitim ve Araştırma Hastanesi Diyabet polikliniğinde 2005-2009 yılları arasında takip edilen 139 hasta çalışmaya dahil edildi. Bu hastalar mikrovasküler komplikasyonu olan (olgu) ve olmayan (kontrol) olarak iki gruba ayrıldı. Hastaların kreatinin, Hba1c, hemogram, hsCRP, albümin, trigliserit ve total-hdlldl kolesterol düzeyleri çalışıldı. Yaş, diyabet yaşı, vücut kitle indeksi ve bel çevreleri değerlendirildi. Hastaları gruplarken dikkate alınan mikrovasküler komplikasyona dair bilgilerine (göz dibi incelemesi-24 saatlik idrar tetkiki) dosyaları incelenerek ulaşıldı. Bulgular: Olgu grubu 49 kadın 34 erkek olmak üzere 83 kişiydi. Kontrol grubu ise 32 kadın 24 erkek 56 kişiydi. Olgu grubunun yaş, diyabet süresi, hemoglobin, hematokrit, kreatinin ve HbA1c değerleri kontrol grubuna göre anlamlı derecede yüksekti. Ayrıca olgu grubunun albümin değeri de kontrol grubuna kıyasla Abs tract Aim: Diabetes is an important cause of mortality and morbidity affecting especially individuals with its complications. We aimed to draw attention to the fact that MPV and hsCRP can be evaluated as warning parameters in terms of development of the complications of diabetes. Methods: 139 patients who were followed up in the diabetes outpatient clinics in Haseki Training and Research Hospital between years 2005-2009 were included in this study. The study group consisted of 83 patients (49 females, 34 males) with microvascular complications. The control group was composed of 56 patients (32 females, 24 males) without microvascular complications. The levels of creatinine, HbA1c, hemogram, hsCRP, albumin, triglyceride and total-HDL-LDL cholesterol were measured in all patients. Age, diabetes age, body mass index and waist circumference were also evaluated. Information about microvascular complications (fundoscopic examination or 24-hour urine investigation) was obtained from the patient files. Results: Age, age of onset of diabetes, hemoglobin, hematocrit, creatinine and HbA1c values in the study group were significantly higher compared to that in the control group. In addition, the albumin values in the study group were lower than in the control group.

Aim: Retrospective, cross-sectional, observational study to examine the frequency and features of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients with myelodysplastic syndrome (MDS). Methods: Data were analyzed from the medical files of 41 MDS patients diagnosed and followed up in the hematology department of a referral center between 2006 and 2017. Descriptive data, cytogenetic and hematologic characteristics, prognostic features and PNH clone sizes were assessed. PNH clone sizes were evaluated using the fluorescently labeled inactive toxin aerolysin (FLAER) method Results: The study population comprised 22 (53.7%) female and 19 (46.3%) male patients with confirmed MDS; the overall mean±SD age was 68.20±9.84 years (range, 45-85). PNH clones were detected in 8 (19.5%) patients. The numbers of patients with PNH clone sizes >10%, >1%, >0.1% and >0.01% were 1, 1, 1 and 8, respectively (p<0.001 for all subgroups). Conclusion

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