The high rate of diarrheal disease in children is caused by many factors, namely, poor hand washing habits, children consuming food that is not guaranteed to be clean, and an unhealthy school environment. One way to prevent the transmission of diarrheal disease is by washing hands with soap. The purpose of this study was to determine the effect of handwashing with soap in preventing diarrhea in school-age children. This study was conducted by searching for national and international journals that match the inclusion criteria through 2 databases, namely Google Scholar and Science Direct. The Study Design used is a Cross Sectional Study. Search articles using keywords that have been adjusted by MeSH. The selection was taken by paying attention to the PICOS framework, then the articles were analyzed one by one. Found 8 national journals and 1 international journal, then the journals were analyzed one by one. The results of the study, namely the majority of articles (8 of 9 articles) stated that there was a significant relationship between the effect of washing hands with soap in preventing diarrhea in school-age children. The conclusion of the study is that there is an effect of hand washing with soap and prevention of diarrhea in school-age children. Suggestions for future researchers are expected not to lean on only one search source and develop a more analytical PICOS design study.