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L ung cancer is known to be the most commonly diagnosed cancer with high mortality and morbidity. Lung cancer is divided into two groups as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). These two groups should be seen as two different diseases concerning their clinical course. 80-85% of newly diagnosed lung cancer patients are NSCLC, and 15-20% is SCLC. According to Turkey cancer statistics in 2017, lung cancer is the first in cancer rate in men (52.5/100.000) and the fifth most common type of cancer in women (8.7/100000). 1-The Role of Radiotherapy in Non-Small Cell Lung Cancer Non-small cell lung cancer (NSCLC), which forms the majority of lung cancers, consists of squamous cell cancer, adenocarcinoma and large cell cancers. Although surgical resection is curative in the group without severe concomitant disease at the early-stage, radiosurgery has taken its place as the standard treatment approach in patients with comorbid disease. However, this group covers only 30% of the patients. [1, 2] Radiotherapy can be applied as definitive in the group with local and regional advanced disease with no surgical chance, as neoadjuvant in the group that has the potential to have surgery and can be applied as adjuvant considering some risk factors after surgery. Radiotherapy in metastatic disease is often used for palliative purposes, but radiosurgery may be an option for metastases in oligometastatic disease. 1A-Early Stage (I-II) Stereotactic Body Radiotherapy or Lung Radiosurgery Radiosurgery, which was introduced to our practice by Swedish brain surgeon Lars Leksell in 1950, was first used in the treatment of brain lesions. With the development Lung cancer is divided into two subgroups concerning its natural course and treatment strategies as follows: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). In this review, for NSCLC, the role of stereotactic body radiation therapy (SBRT) in early-stage, chemoradiation in the locally advanced stage, post-operative radiotherapy for patients with high risk after surgery and radiotherapy for metastatic disease will be discussed. Also, for SCLC, the role and timing of thoracic irradiation and prophylactic cranial irradiation (PCI) for the limited and extensive stages will be discussed.

Purpose and Objective: To evaluate the disease-free survival, overall survival, dosimetric, and voice handicap index (VHI) results of T1a glottic invasive squamous cell carcinoma (SCC) patients who underwent hypofractionated single vocal cord irradiation (HSVCI). Materials and Methods: The data of 18 patients with stage T1a glottic SCC were collected prospectively and analyzed retrospectively between July 2016 and July 2019. Patients were immobilized using a custom-fitted thermoplastic face and shoulder mask in hyperextension position. The CT scan was performed with 1-mm-thick slices. A planned target volume (PTV) margin of 3 mm was given to clinical target volume (CTV) in all directions, and 13 organs at risk were identified. Patients were prescribed a total of 5760-5808 cGy in 15-16 fractions. Patients had daily cone-beam computed tomography (CBCT), and the treatment was carried out with the physician. VHI test was applied to patients before and at the end of radiotherapy (RT) and 1, 2, 3, 4, and 6 months after the completion of RT. Results: Local control and overall survival rate is 100% for a median of 18 months (6-44 months) of follow-up. A patient was diagnosed with 2nd primary lung cancer and active treatment still continues. All patients completed the treatment within the scheduled time. Grade 1-2 dysphagia and dermatitis occurred in all patients, and no grade 3 and above side effects were observed. The mean values of VHI were 37.

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