Steroidal building blocks have drawn research groups attention in many branches of science and technology, such as pharmacological and medical fields, supramolecular chemistry and compounds in nanotechnology, So the recent years have witnessed a wide focus of research directed towards preparing heterocyclic derivatives fused with steroid molecules as a result of the great biological activity these compounds, This review described an outline of the literature reports (2014-2020) of synthesis heterocyclic compounds for steroid molecules fused at rings-A or B or D of steroid skeleton or annealed, Also the review included the biological activity of steroid hetero cyclic as anti breast cancer, anti prostate cancer, antioxidant and antimicrobial.

Some new derivatives ofsuberic chloride synthesized by reactionssuberoyl chloride with 4-amino acetophenoneto prepare N 1 ,N 8 -bis(4-acetylcyclohex-2-en-1-yl)octanediamide,then react with 4-nitrobenzaldehydein the presence of sodium hydroxide,the product reacted with (urea,thiourea, phenyl hydrazine, 2-amino aniline,2-aminophenol, 2,4-dinitrophenyl hydrazine and 2-amino benzothiol) to prepare many hetrocyclicderivatives. This reaction was checked by thin-layer chromatography (TLC) method. All new compounds were characterized by melting points, elemental analysis, FT-IR, 1 H& 13 C-NMR. The antibacterial action of these derivatives was determined.