A simple and efficient synthesis of 11H-pyrido[2,1-b]quinazolin-11-ones by Cu(OAc)2·H2O-catalyzed reaction of easily available substituted isatins and 2-bromopyridine derivatives has been developed. The reaction involves C-N/C-C bond cleavage and two C-N bond formations in a one-pot operation. This methodology is complementary to previously reported synthetic procedures, and two plausible reaction mechanisms are discussed.

An efficient three-component synthesis of o-hydroxyphenyl-substituted pyrazolo[3,4-b]pyridines from substituted salicylic aldehydes, β-keto esters and 5-aminopyrazoles in the presence of FeCl3 is presented. Newly synthesized compounds were fully characterized by means of 1H NMR, 13C NMR, IR, HRMS and elemental analysis.

The copper‐catalyzed reaction of isatins (I) with 2‐bromopyridines (II) leads to a variety of pyrido‐fused quinazolinones (III).

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