Global responses to the coronavirus disease 2019 (COVID19) pandemic are converging with pervasive, existing sexual and reproductive health and justice inequities to disproportionately impact the health, wellbeing, and economic stability of women, girls, and vulnerable populations. People whose human rights are least protected are likely to experience unique difficulties from COVID19. 1 Women, girls, and marginalised Centring sexual and reproductive health and justice in the global COVID-19 response unmonitored isolation, from the effects of COVID19, as well as loneliness and mental health deterioration. The risks of using CHWs in this way could be reduced by supervision, with independent monitoring and evaluative research to identify problems early and correct them. The CHWs could visit in pairs to reduce the risks.People might resist or be reluctant to be visited by CHWs, and they could opt out of home visits at any time, but experience with CHWs in Brazil in the past 30 years suggests this would happen rarely. 4 In Brazil, 250 000 CHWs provide a much needed and relied upon service. CHWs in Brazil have been established for many years, are well integrated into their communities, and provide a wide range of health and social care support activities to each of the 100-150 households that they are responsible for. Therefore, in Brazil, additional roles for preventing the spread of and supporting those infected with COVID19 or in selfisolation could be integrated into the work of CHWs. Much can be learned from countries with successful experiences of radical, largescale workforce interventions. 9 It could be argued that this is an unrealistic proposal and that adapting the existing system or training so many people is too challenging. However, current health and social care systems in the UK are under extreme pressure and could become overwhelmed. In a time of fear, isolation, and growing health inequalities, 10 use of CHWs for the COVID19 response would boost social coherence and fill gaps that have begun to emerge between health and social care and inperson and virtual access to health care. Our proposal for CHWs would produce a large cadre of people with an understanding of basic epidemiological and public health concepts 11 who could challenge scientific misinformation and explain the rationale for specific health policies and interventions to the public. This approach would also help build a new generation of leaders who can help tackle the complex challenges of our age.

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Population structure and patterns of habitat use among ringed seals (Phoca hispida) are poorly known, in part because seasonal movements have not been adequately documented. We monitored the movements of 98 ringed seals in the Beaufort and Chukchi seas between 1990 and 2006 using three forms of telemetry. In the winter-spring period (when the seals were occupying shorefast ice), we used radio and ultra-sonic tags to track movements above and below the ice, respectively. We used satellite-linked transmitters in summer and fall (when the seals ranged away from their winter sites) to track at-sea movements. In the shorefast ice habitat, the home ranges of 27 adult males ranged from \1 to 13.9 km 2 (median = 0.628) while the home ranges of 28 adult females ranged from \1 to 27.9 km 2 (median = 0.652). The 3-dimensional volumes used by 9 seals tracked acoustically under the ice averaged 0.07 (SD = 0.04) km 3 for subadults and adult males and 0.13 (SD = 0.04) km 3 for adult females. Three of the radio-tracked seals and 9 tracked by satellite ranged up to 1,800 km from their winter/spring home ranges in summer but returned to the same small (1-2 km 2 ) sites during the ice-bound months in the following year. The restricted movements of ringed seals during the ice-bound seasonincluding the breeding season-limits their foraging activities for most of the year and may minimize gene flow within the species.

The rhythm of life on earth is shaped by seasonal changes in the environment. Plants and animals show profound annual cycles in physiology, health, morphology, behaviour and demography in response to environmental cues. Seasonal biology impacts ecosystems and agriculture, with consequences for humans and biodiversity. Human populations show robust annual rhythms in health and well-being, and the birth month can have lasting effects that persist throughout life. This review emphasizes the need for a better understanding of seasonal biology against the backdrop of its rapidly progressing disruption through climate change, human lifestyles and other anthropogenic impact. Climate change is modifying annual rhythms to which numerous organisms have adapted, with potential consequences for industries relating to health, ecosystems and food security. Disconcertingly, human lifestyles under artificial conditions of eternal summer provide the most extreme example for disconnect from natural seasons, making humans vulnerable to increased morbidity and mortality. In this review, we introduce scenarios of seasonal disruption, highlight key aspects of seasonal biology and summarize from biomedical, anthropological, veterinary, agricultural and environmental perspectives the recent evidence for seasonal desynchronization between environmental factors and internal rhythms. Because annual rhythms are pervasive across biological systems, they provide a common framework for trans-disciplinary research.

6Biological rhythms-from circadian control of cellular processes to annual cycles in life history-are 7 a main structural element of biology. Biological rhythms are considered adaptive because they allow 8 organisms to partition activities to cope with, and take advantage of, predictable fluctuations in 9 environmental conditions. A flourishing area of immunology is uncovering rhythms in the immune 10 system of animals, including humans. Given the temporal structure of immunity, and rhythms in 11 parasite activity and disease incidence, we propose that the intersection of Chronobiology, Disease 12Ecology and Evolutionary Biology holds the key to understanding host-parasite interactions. We 13 review host-parasite interactions while explicitly considering biological rhythms, and propose that 14(1) rhythms influence within-host infection dynamics and transmission between hosts, (2) rhythms 15 might account for diel and annual periodicity in host-parasite systems, and (3) rhythms can lead to 16 a host-parasite arms race in the temporal domain. Interactions between hosts and parasites (i.e., microparasites and macroparasites) are embedded within 77 environmental rhythms ( Figure 1A). In addition to the environment, host immunity imposes selective 78 pressure on parasites, whilst parasite-driven morbidity and mortality reduces host fitness. These multiple 79 selective forces make optimal timing of allocation of limited resources to survival and reproduction 80