ObjectivesTo investigate the characteristics, methodology, quality, and efficacy of psychological interventions for distress in adult patients undergoing haematopoietic stem cell transplantation (HSCT).
MethodsA systematic review of relevant studies was conducted using six databases with supplementary hand searching. Included studies employed an experimental or quasiexperimental design, interventions included at least one psychological component, and outcomes involved psychological distress in affective terms. Data were abstracted and study quality was assessed using Cochrane Foundation criteria amended to include confounder and common factors control. Data were examined and synthesised using a narrative approach and meta-analysis.
ResultsEleven articles for nine interventions met the inclusion criteria out of 11741 abstracts.The studies varied in quality, general, intervention, and methodological characteristics while findings were mixed. Interventions tended to show better efficacy when incorporating a major psychological component involving cognitive behavioural or emotional processing methods with substantial interventionist input. However, this was also associated with methodological limitations and threats to internal validity such as poor confounder and common factors control. A meta-analysis yielded a small but significant pooled effect size estimate in favour of interventions with inconsequential heterogeneity. Risk of bias remained a concern.
ConclusionsPsychological interventions may provide some benefit in alleviating distress in HSCT but conclusions remain tentative in light of methodological limitations and risk of bias.Further research is needed to evidence the individual contribution of intervention components and mechanism of change together with improving intervention efficiency and methodological quality.
Psychological distress in HSCT and its sequelaeIn light of the physical burden, it is not surprising that patients experience considerable psychological distress. Patients report a consuming effort to prepare and an ongoing struggle, describing the procedure as "walk to hell and back" or "really, really hard" [8, p. 404]. Studies in adult HSCT have observed considerable psychological distress, particularly during hospitalisation, with up to a quarter of patients meeting clinical criteria for anxiety and/or depression [3,[9][10][11][12][13]. Following transplantation, psychological distress improves but can persist with up to 40% of patients experiencing depression and up to 30% anxiety even one year later [14].Apart from psychological well-being, distress also appears to affect physical wellbeing and recovery although research remains limited and correlational. Studies have observed associations between psychological distress and worse treatment adherence, reduced pain and symptom tolerance, longer hospital stay, and higher mortality [11,12,15].In addition, stress has been associated with greater subsequent incidence of illness, harmful physiological changes, greater pain perceptio...