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SUMMARYIn an effort to improve on the noninvasive detection of renal artery stenosis, we investigated the effect of angiotensin converting enzyme inhibition on computer-assisted Tc-diethylenetriaminepentaacetic acid (DTPA) renal flow studies in a canine model of two-kidney, one clip hypertension and compared these findings with clearances of inulin and p-aminohippuric acid in the stenotic and contralateral kidney before and after converting enzyme inhibition. The T c -D T P A renal flow study with the converting enzyme inhibitor captopril (1.5 mg/kg bolus with 1.5 mg/min infusion) showed an increased sensitivity in the detection of unilateral renal artery stenosis over the use of the T c -D T P A study alone. Captopril induced striking alterations that were most evident in the 15-minute T c -D T P A renal flow study, in which all nine curves exhibited severely blunted uptake and excretion of the radionuclide. These changes were reversed during a recovery study without converting enzyme inhibition and were not seen when blood pressure was lowered with nitroprusside to a level similar to that observed during converting enzyme inhibition We reported the development of a computer-assisted Tc-diethylenetriaminepentaacetic acid (DTPA) renal flow study in a group of patients with angiographically proven RVHT and preserved renal function 3 and in a canine model of two-kidney, one clipFrom the

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