What sort of psychotherapeutic approaches might work well with a client who identifies as Muslim, and would they be different from what might work well with a client who identifies as Christian, a client who identifies as atheistic, or client who identifies as Buddhist? Despite ethical commitments to religiosity and spirituality training, it seems that most training programs in professional psychology have neglected to incorporate content from these areas of diversity into their curricula. The current study evaluated religious and spiritual diversity training in both APA-accredited doctoral programs and predoctoral internships, garnering the perspectives of 292 students, interns, faculty, and training directors (54.9% response rate). Results revealed a clear hierarchy of preparatory efforts with regard to diversity training, with least attention given to the dimensions of diversity pertaining to disabilities, age, religion, and spirituality. Participants also perceived several areas of advanced competency to be neglected, including preparation efforts related to consultation with religious and spiritual leaders and understanding the major world religions and spiritual systems. The findings also revealed that doctoral programs and predoctoral internships rely on informal and unsystematic sources of learning to provide training in religious and spiritual dimensions of diversity, including clinical experiences and peer interaction. Coursework, research, and didactics are rarely used to enhance religious and spiritual diversity training. Implications regarding current perceptions of training in religious and spiritual diversity are included.
Sepsis is defined as the systemic, dysregulated host immune response to an infection that leads to injury to host organ systems and, often, death. Complex interactions between pathogens and their hosts elicit microcirculatory dysfunction. Neutrophil myeloperoxidase (MPO) is critical for combating pathogens, but MPO-derived hypochlorous acid (HOCl) can react with host molecular species as well. Plasmalogens are targeted by HOCl, leading to the production of 2-chlorofatty acids (2-CLFAs). 2-CLFAs are associated with human sepsis mortality, decrease in vitro endothelial barrier function, and activate human neutrophil extracellular trap formation. Here, we sought to examine 2-CLFAs in an in vivo rat sepsis model. Intraperitoneal cecal slurry sepsis with clinically relevant rescue therapies led to ∼73% mortality and evidence of microcirculatory dysfunction. Plasma concentrations of 2-CLFAs assessed 8 h after sepsis induction were lower in rats that survived sepsis than in nonsurvivors. 2-CLFA levels were elevated in kidney, liver, spleen, lung, colon, and ileum in septic animals. In vivo, exogenous 2-CLFA treatments increased kidney permeability, and in in vitro experiments, 2-CLFA also increased epithelial surface expression of vascular cell adhesion molecule 1 and decreased epithelial barrier function. Collectively, these studies support a role of free 2-CLFAs as biomarkers of sepsis mortality, potentially mediated, in part, by 2-CLFA-elicited endothelial and epithelial barrier dysfunction.
larger discipline of Christian psychology-we offer more of a micro perspective by considering how professional psychologists may value church involvement in their personal and professional lives.
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