The WNT (Wingless/Integrated) signaling pathway is implicated in various stages of glioblastoma, which is an aggressive brain tumor for which therapeutic options are limited. WNT has been recognized as a hallmark of therapeutic challenge due to its context-dependent role and critical function in healthy tissue homeostasis. In this review, we deeply scrutinize the WNT signaling pathway and its involvement in the genesis of glioblastoma as well as its acquired therapy resistance. We also provide an analysis of the WNT pathway in terms of its therapeutic importance in addition to an overview of the current targeted therapies under clinical investigation.

nequalities in leg length, whether anatomical o r cre-21 ated by artificial means (such J as lifts), are known to have i i some specific effects on the posture of standing individuals. Among the effects of leg length discrepancies are lateral pelvic tilts (1, 2, 8). scoliotic curves (2, 3), and alterations in weight bearing patterns (8). Potentially more important than these effects, however, is the possible association between leg length discrepancies and low back pain. Although all studies of the issue have not shown leg length discrepancies to be an important factor in back pain (7), several reports have suggested that leg length inequalities may be worth addressing in patients with back pain (4, 5).T h e valid clinical identification of leg length discrepancies presupposes that the methods used to quantify leg length result in accurate and reliable measurements. T h e degree to which measurements of leg length obtained using surface landmarks have been shown to accurately reflect radiographic measurements of leg length varies between studies. Although the former measures can differ substantially from the latter (3, 10, 1 l), high reliabilitv coefficients (.99