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The postmortem remains of sixty-one war victims were excavated from 6 mass graves in Bosnia and Herzegovina one and a half years after interment. Using standard identification methods, including the matching of medical and dental records, the recognition of distinguishing characteristics such as the use of clothing and belongings, and video superimposition, 35 persons were identified. For the remaining 26 persons identification efforts continue. DNA typing was performed at the HLA DQA1 locus and five PM system loci. Results from DNA typing were confirmed by other methods. DNA profiles of family members of 150 missing persons are now being developed using the 6 loci. These DNA profiles will then be compared with those generated from the bone and teeth remains of the unidentified victims.

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In order to study whether phosphate transfer reactions are involved in the binding of guanine nucleotide triphosphates to guanine-nucleotide-binding regulatory proteins, binding of the GTP analogues, guanosine 5'-[y-thioltriphosphate, GTP [S], and guanosine 5'-[j?,y-imino]triphosphate, p [NH]ppG, and the regulation of binding by the fonnyl-peptide-receptor agonist, Net-Leu-Phe, were studied in membranes of differentiated HL-60 cells. For met-Leu-Phe-stimulated binding of either GTP analogue, a competing nucleotide was required. With GDP as the competing nucleotide, initial rates of Met-Leu-Phe-stimulated binding of GTP [S] Guanine-nucleotide-binding regulatory proteins (G proteins) participate in many transmembrane signalling pathways, coupling a large variety of membrane receptors to second-messenger-generating enzymes and ion channels. These G proteins are heterotrimers composed of a, j?, and y subunits, the latter two forming a j?y dimer under non-denaturating conditions [l-31. The activation of G proteins is generally assumed to be caused by receptor-induced exchange of GDP bound to G protein a subunits by GTP. We have recently reported that / 3 subunits of the retinal G protein