The All-sky Medium Energy Gamma-ray Observatory (AMEGO) is a probe class mission concept that will provide essential contributions to multimessenger astrophysics in the late 2020s and beyond. AMEGO combines high sensitivity in the 200 keV to 10 GeV energy range with a wide field of view, good spectral resolution, and polarization sensitivity. Therefore, AMEGO is key in the study of multimessenger astrophysical objects that have unique signatures in the gamma-ray regime, such as neutron star mergers, supernovae, and flaring active galactic nuclei. The order-of-magnitude improvement compared to previous MeV missions also enables discoveries of a wide range of phenomena whose energy output peaks in the relatively unexplored medium-energy gamma-ray band.

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Evidence for the presence of cortisol and corticosterone in equine plasma and cortisol in equine urine is presented. The mean morning concentration of plasma cortisol was 7 \g=m\g/100ml, and that of corticosterone 0\m=.\5 \ g=m\ g/ 100 ml.A diurnal rhythm of small amplitude was found.Administration of corticotrophin, induction of hypoglycaemia and surgery produced marked increases in plasma cortisol levels, but only small increases were seen after normal exercise. The changes in plasma cortisol were not invariably accompanied by significant alteration of the eosinophil count.

In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans (Man5-9GlcNAc2), expressed on diseased or oxidized RBC surfaces, bind the mannose receptor (CD206) on phagocytes to mediate clearance. We find that extravascular hemolysis in sickle cell disease correlates with high mannose glycan levels on RBCs. Furthermore, Plasmodium falciparum-infected RBCs expose surface mannose N-glycans, which occur at significantly higher levels on infected RBCs from sickle cell trait subjects compared to those lacking hemoglobin S. The glycans are associated with high molecular weight complexes and protease-resistant, lower molecular weight fragments containing spectrin. Recognition of surface N-linked high mannose glycans as a response to cellular stress is a molecular mechanism common to both the pathogenesis of sickle cell disease and resistance to severe malaria in sickle cell trait.

Digital objects or entities present us with particular problems of an acute nature. The most acute of these are the issues surrounding what constitutes identity within the digital world and between digital entities. These are problems that are important in many contexts but, when dealing with digital texts, documents, and certification, an understanding of them becomes vital legally, philosophically, and historically. Legally, the central issues are those of authorship, authenticity, and ownership; philosophically, we must be concerned with the sorts of logical relations that hold between objects and in determining the ontological nature of the object; and historically, our concern centers around our interest in chronology and the recording of progress, adaptation, change, and provenance. Our purpose is to emphasize why questions of digital identity matter and how we might address and respond to some of them. We will begin by examining the lines along which we draw a distinction between the digital and the physical context and how, by importing notions of transitivity and symmetry from the domain of mathematical logic, we might attempt to provide at least interim resolutions of these questions.