The purpose of this in vitro study was to compare the precision of fit of substructures milled from semi-sintered zirconia blocks fabricated with two different computer-assisted design (CAD)/computer-assisted manufacturing (CAM) systems. Three-unit posterior fixed dental prostheses (FDP) were fabricated for standardized dies (n = 10) with the Lava CAD/CAM system (Lava) and the Procera-bridge-zirconia CAD/CAM system (Procera). After cementation to the dies, the FDP were embedded and sectioned. Four cross-sections were made of each abutment tooth, and marginal and internal fit were evaluated under an optical microscope. A one-way analysis of variance was used to compare data (alpha = 0.05). Mean gap dimensions at the marginal opening for Lava and Procera were 15 (+/-7) microm and 9 (+/-5) microm, respectively. Mean marginal openings (P = 0.012) and internal adaptation at two out of three measurement locations were significantly different. Within the limitations of this study, the results suggest that the accuracy of both investigated systems is satisfactory for clinical use.
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