The findings highlight relative age effects are prevalent across the female sport contexts examined. Relative age effect magnitude is moderated by interactions between developmental stages, competition level and sport context demands. Modifications to sport policy, organisational and athlete development system structure, as well as practitioner intervention are recommended to prevent relative age effect-related participation and longer term attainment inequalities.

Background and Purpose-The purpose of this study was to demonstrate a new approach to the use of a self-expanding stent in the treatment of acute ischemic stroke. Methods-Twenty-two consecutive patients with acute intracerebral artery occlusions were treated with a self-expandable intracranial stent, which was withdrawn in its unfolded state. For this technique, we used the Solitaire AB/FR, which is the only intracranial stent that is fully recoverable. Eight patients had an occlusion of the basilar artery, 12 had a middle cerebral artery occlusion, and 2 had terminal carotid artery occlusions; 6 of these had to be treated first for an acute occlusion originating in the internal carotid artery. Recanalization results were assessed by follow-up angiography immediately after the procedure. Neurologic status was evaluated before and after treatment (90-day follow-up) according to the National Institutes of Health Stroke Scale and modified Rankin scale. Results-Successful revascularization was achieved in 20 of 22 (90.9%) patients (thrombolysis in cerebral infarction[TICI] 2a/b and 3), a TICI 3 state was accomplished in 12 patients, and partial recanalization or slow distal branch filling with filling of more than two-thirds of the vessel territory was achieved in 8 patients (TICI 2b). There was immediate flow restoration in 21 of 22 (95.4%) cases after deployment of the device. The stent was removed in its unfolded state in all patients. The mean time from stroke symptom onset to recanalization was 277 minutes, with a standard deviation of 118 minutes. Mean National Institutes of Health Stroke Scale score on admission was 19.4, with a standard deviation of 5.7. Almost two-thirds of the patients (63.6%) improved by Ͼ10 points on the National Institutes of Health Stroke Scale at discharge, and 50% showed a modified Rankin scale score of Յ2 at 90 days (59% with a modified Rankin scale Յ3). Mortality was 18.1%. In 1 case, an asymptomatic intracranial hemorrhage was detected on control computed tomography, and 2 patients had a symptomatic intracranial hemorrhage. Conclusion-Withdrawal of an unfolded, fully recoverable, intracranial stent yielded very promising angiographic and clinical results. It combines the advantages of prompt flow restoration and mechanical thrombectomy. (Stroke.

Relative Age Effects (RAEs) refer to the selection and performance differentials between children and youth who are categorized in annual-age groups. In the context of Swiss 60m athletic sprinting, 7761 male athletes aged 8 – 15 years were analysed, with this study examining whether: (i) RAE prevalence changed across annual age groups and according to performance level (i.e., all athletes, Top 50%, 25% & 10%); (ii) whether the relationship between relative age and performance could be quantified, and corrective adjustments applied to test if RAEs could be removed. Part one identified that when all athletes were included, typical RAEs were evident, with smaller comparative effect sizes, and progressively reduced with older age groups. However, RAE effect sizes increased linearly according to performance level (i.e., all athletes – Top 10%) regardless of age group. In part two, all athletes born in each quartile, and within each annual age group, were entered into linear regression analyses. Results identified that an almost one year relative age difference resulted in mean expected performance differences of 10.1% at age 8, 8.4% at 9, 6.8% at 10, 6.4% at 11, 6.0% at 12, 6.3% at 13, 6.7% at 14, and 5.3% at 15. Correction adjustments were then calculated according to day, month, quarter, and year, and used to demonstrate that RAEs can be effectively removed from all performance levels, and from Swiss junior sprinting more broadly. Such procedures could hold significant implications for sport participation as well as for performance assessment, evaluation, and selection during athlete development.

BackgroundEarly treatment with rt-PA is critical for favorable outcome of acute stroke. However, only a very small proportion of stroke patients receive this treatment, as most arrive at hospital too late to be eligible for rt-PA therapy.Methods and FindingsWe developed a “Mobile Stroke Unit”, consisting of an ambulance equipped with computed tomography, a point-of-care laboratory system for complete stroke laboratory work-up, and telemedicine capabilities for contact with hospital experts, to achieve delivery of etiology-specific and guideline-adherent stroke treatment at the site of the emergency, well before arrival at the hospital. In a departure from current practice, stroke patients could be differentially treated according to their ischemic or hemorrhagic etiology even in the prehospital phase of stroke management. Immediate diagnosis of cerebral ischemia and exclusion of thrombolysis contraindications enabled us to perform prehospital rt-PA thrombolysis as bridging to later intra-arterial recanalization in one patient. In a complementary patient with cerebral hemorrhage, prehospital diagnosis allowed immediate initiation of hemorrhage-specific blood pressure management and telemedicine consultation regarding surgery. Call-to-therapy-decision times were 35 minutes.ConclusionThis preliminary study proves the feasibility of guideline-adherent, etiology-specific and causal treatment of acute stroke directly at the emergency site.

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