Ethanol place-preference conditioning (PC) was conducted in drug-naive and ethanol pre-exposed female and male C57BL/6J (C57) mice to assess whether environmental cues can develop positive incentive value for ethanol-preferring animals when associated with administration of ethanol. After 12 days episodic access to free-choice ethanol and/or water self-administration, mice received eight ethanol injections (1.75 g/kg/i.p.) 5 min before placement in their nonpreferred PC chamber and eight saline injections paired with their preferred chamber. Control mice received eight saline injections (20 ml/kg) in both their preferred and nonpreferred chambers. Mice of both sexes developed strong ethanol PC. Correlational analysis indicated that the strength of ethanol PC for mice with a prior ethanol drinking experience was inversely related to the amount of ethanol consumed regardless of gender. Furthermore, depending on gender and previous ethanol drinking experience, ethanol PC was differentially related to initial baseline motor activity, the initial motor response to ethanol, or rapid change in the motor response to ethanol. Thus, a complicated relationship between neural systems that mediate ethanol reward and motor activity may exist as suggested by current addiction theory.

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