This paper presents and visualizes examples of large amounts of genetic information using a new class of cognitive computer graphics algorithms. These algorithms are related to the semiotics of perception and allow the interpretation of those properties of nucleotide sequences that are difficult to perceive by simple reading or by standard means of statistical analysis. This article summarizes previously presented algorithms for visualizing long nucleic acids based on the primary Hadamard–Walsh function system. The described methods allow us to produce one-dimensional mappings of nucleic acids by levels corresponding to their scale-integral physicochemical parameters and construct a spectral decomposition of the nucleotide composition. An example of the spectral decomposition of parametric representations of molecular genetic structures is given. In addition, a multiscale composition of genetic functional mappings visualizing the structural features of nucleic acids is discussed.
Coronaviruses are viruses that infect the respiratory system of humans. Besides high mortality rates among the population, they brought about several economic crises on a global scale. Methods. To study and identify features in the genetic composition of the nucleotide sequences of various coronaviruses, we applied copyright algorithms and visualization, which allowed us to compare the biochemical parameters of diverse RNA coronaviruses in a visual form. Results. The article provides examples of different approaches to imaging coronaviruses. We have provided examples of coronavirus RNA structure visualization in various parametric spaces (1-D and 2-D). We employed various visualization types, including structural, integral, and frequency. The research discussed methods of visualization. Our team developed visualization and comparative analysis of coronavirus serotypes and visualization of SARS-CoV-2 coronavirus datasets. Discussion followed on the visualization results. The presented techniques and the results allowed for displaying the structure of RNA sequences of coronaviruses in spaces of various dimensions. Conclusions. According to our findings, the proposed method contributes to the visualization of the genetic coding of coronaviruses. We discussed the issues of machine learning and neural network technology concerning the analysis of coronaviruses based on the presented approach. The described line of research is essential for the study and control of complex quantum mechanical systems, such as RNA or DNA.
This article describes new algorithms that allow for viewing genetic sequences in the form of their multispectral images. We presented examples of the construction of such mappings with a demonstration of the practical problems of comparative genomics. New DNA visualization tools seem promising, thanks to their informativeness and representativeness. The research illustrates how a novel sort of multispectral mapping, based on decomposition in several parametric spaces, can be created for comparative genetics. This appears to be a crucial step in the investigation of the genetic coding phenomenon and in practical activities, such as forensics, genetic testing, genealogical analysis, etc. The article gives examples of multispectral parametric sets for various types of coordinate systems. We build mappings using binary sub-alphabets of purine/pyrimidine and keto/amino. We presented 2D and 3D renderings in different characteristic spaces: structural, integral, cyclic, spherical, and third-order spherical. This research is based on the method previously developed by the author for visualizing genetic information based on new molecular genetic algorithms. One of the types of mappings, namely two-dimensional, is an object of discrete geometry, a symmetrical square matrix of high dimension. The fundamental properties of symmetry, which are traced on these mappings, allow us to speak about the close connection between the phenomenon of genetic coding and symmetry when using the developed mathematical apparatus for representing large volumes of complexly organized molecular genetic information.
Color visualization of the DNA of diverse living beings can help in the exploration of the issue of chromatic differentiation of functional mappings of the nucleotide composition of DNA molecules. By “chromatic differentiation”, we mean the coloring of these mappings. Algorithms for coloring genetic representations improve the perception of complex genetic information using color. Methodologically, to build the chromatic differentiation of functional mappings of the nucleotide composition of DNA, we employed the system of nucleotide Walsh functions and the Chaos Game Representation (CGR) algorithm. The authors compared these two approaches and proposed a modified CGR algorithm. The work presents various algorithms of chromatic differentiation based on the nucleotide Walsh functions at a specific location of the fragment in the nucleotide chain and on the frequencies of those fragments. The results of the analysis provide examples of chromatic differentiation in a variety of parametric spaces. The paper describes various approaches to coloring and video animation of DNA molecules in their chromatically differentiated spans of physicochemical parameters.
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