BACKGROUND:The authors evaluated the feasibility, toxicity, and efficacy of gefitinib added to first‐line combined‐modality therapy for patients with locally advanced squamous carcinoma of the head and neck.METHODS:Patients with biopsy‐proven locally advanced squamous carcinoma of the head and neck who had low expected cure rates with local treatment modalities alone were eligible for this treatment. All patients received a 6‐week induction course of docetaxel, carboplatin, infusional 5‐fluorouracil, and gefitinib (250 mg daily). Gefitinib was continued while patients received concurrent weekly docetaxel and radiation therapy. After the completion of radiation therapy, gefitinib was continued until patients developed disease progression or for a maximum of 24 months.RESULTS:Sixty‐two patients (53% with stage IV disease) received protocol treatment, and 50 patients (81%) were able to complete the regimen. The addition of gefitinib increased the incidence of grade 3/4 mucositis (27%) and diarrhea (16%) during induction therapy but did not appear to add substantially to toxicity during concurrent chemoradiation. The estimated 3‐year progression‐free and overall survival rates for the entire group were 41% and 54%, respectively.CONCLUSIONS:The addition of gefitinib was associated with a moderate increase in toxicity with this combined modality regimen, particularly during induction therapy. Although this regimen was efficacious, the survival results overlap with results reported with chemoradiation alone. The role of epidermal growth factor receptor inhibitors in first‐line, combined‐modality therapy for patients with head and neck cancer remains undefined. Cancer 2009. © 2009 American Cancer Society.

Syndiotactic polypropylenes and their copolymers with 1‐olefins were synthesized using two metallocene/MAO catalytic systems, and the effect of the different microstructures on nonisothermal crystallization and subsequent melting was studied. Using differential scanning calorimetry (DSC) it was observed that samples with lower content of defects showed crystallization on cooling from the melt, and a double melting peak in the subsequent heating scan, the latter associated with melt, recrystallization and remelt processes that it was confirmed by its nonreversing exothermic process found by means of temperature modulated DSC (MDSC). However, polymers with high amount of defects showed cold crystallization on heating followed by a melting process, that it was observed by MDSC. Wide angle X‐ray diffraction was used for characterizing the changes of crystalline forms in relationship with crystallization process. © 2008 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 46: 798–806, 2008

Endodermal sinus tumor (EST) of the mediastinum is a rare germ‐cell neoplasm affecting mainly young adult males. Ten patients with EST were treated with a multimodality approach that included surgery, chemotherapy, and radiotherapy. All patients had relapses after achieving a transient response except one who is still in complete remission more than five years following the diagnosis of the disease. Optimal therapy for this neoplasm has yet to be discovered. The disease is a subset of extragonadal germ cell tumors which appears to be lethal in most cases, particularly when the primary tumor is unresectable. The first case of five‐year disease‐free survival is described.

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