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Anemia as the cause of clinical inability of candidates to blood donation for a hemotherapy and hematology center in the state of Maranhão, BrazilAnemia como causa da inaptidão clínica em candidatos a doação de sangue em um ABSTRACT Objective: To evaluate anemia as a cause of clinical disability in blood donors in the state of Maranhão-Brazil. Methods: This study addresses a time series of prevalence of anemia among blood donor candidates. Secondary data were collected from the Information System of the Blood Center of Maranhão. Donor candidates were treated between 2001 and 2010. Statistical analysis was performed with Epi Info version 6.04d. Results: The proportion of clinical disability was 16.8% (n = 1,672) and 63.27% (n = 6,198) consisted of men. Considering the unfit group,anemia was the second most frequent cause with 16.68% (n = 16,729). In men, drug use was the most frequent cause of inability (90.94%, n = 650) and anemia was the last cause with 28.76% (n = 458). In women, anemia was the major cause of clinical inability (71.24%, p = 0.000). Conclusion: Anemia is an important cause of inability, and in women it is the first one. RESUMOObjetivo: Avaliar a anemia como causa de inaptidão clínica de candidatos a doação de sangue no estado do Maranhão. Métodos: Este estudo trata de uma série temporal da prevalência de anemia entre os candidatos doadores de sangue. Foram coletados dados secundários do Sistema de Informação do Hemocentro do Maranhão. Os candidatos a doação foram atendidos entre os anos de 2001 e 2010. A análise estatística foi realizada com Epi Info versão 6.04d. Os dados foram considerados estatisticamente significativos quando p <0,05. Resultados: A proporção de inaptidão clínica foi de 16,8% (n=1,672) sendo desses 63,27% (n=6,198) eram homens. Considerando-se o grupo de inaptos, a anemia foi a segunda causa mais frequente com 16.68% (n= 16,729). Nos homens,

Introduction: Chronic kidney disease (CKD) is a global public health problem, which implies poor health and high risk of cardiovascular disease contributing to high mortality rates, whichhas been associated with high levels of alkaline phosphatase (AF) in this public. The aim of this study was to compare clinical and biochemical parameters in relation to alkaline phosphatase levels of chronic renal patients on hemodialysis. Methods: Cross-sectional and analytical study, performed in 93 male and female patients, aged 18 years or older, from a hemodialysis center in the city of Belém, Pará. Data collection included interviews through a semi-structured questionnaire and consultation of medical records. Descriptive statistics consisted of mean, standard deviation, median, interquartile range, relative and absolute frequency. For alkaline phosphatase analysis, the interquartile range of 120 U/L was used. Results: Of the 93 patients, 58 were men with a mean age of 54.5 ± 4.5 years. The sample was divided into two groups: the first, with low alkaline phosphatase - less than 120 U/L (n= 50; 82.24 ± 21.67); and the second, with high alkaline phosphatase - greater than or equal to 120 U/L (n= 43; 288.82 ± 300.05). After analyzing the clinical and biochemical profile of each group, we found a statistical difference in the values of parathyroid hormone and hemoglobin, in which the group with high alkaline phosphatase obtained higher parathyroid hormone levels and lower hemoglobin values. Considerable prevalence of elevated phosphatase was observed in chronic renal patients on hemodialysis. Conclusion: The study identified high parathyroid hormone and lower hemoglobin in patients with high alkaline phosphatase. We emphasize the importance of monitoring and correcting AF levels, when possible.