δ‐Hydroxy‐β‐keto esters and δ,β‐dihydroxy esters are characteristic structural motifs of statin‐type natural products and drug candidates. Here, we describe the synthesis of functionalized δ‐hydroxy‐β‐keto esters in good yields and excellent enantioselectivities using Chan's diene and modified Mukaiyama‐aldol reaction conditions. Diastereoselective reduction of δ,β‐dihydroxy esters afforded the respective syn‐ and anti‐diols, and saponification yielded the corresponding acids. All products were evaluated for their anti‐inflammatory properties, which uncovered a surprising structure‐activity relationship.

Les exploitations agricoles doivent leur résultat financier à une combinaison entre leur taille physique et la productivité de leur système de production. L’objet de l’article est de la préciser à l’échelle des régions agricoles de l’ouest de la France grâce à l’utilisation de la comptabilité agricole.

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The author tries a comparaison between the agricultural land use of two countries concerned by aridity : California and central Asia.

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