The design and performance of the active complex electrode (ACE1) electrical impedance tomography system for single-ended phasic voltage measurements are presented. The design of the hardware and calibration procedures allows for reconstruction of conductivity and permittivity images. Phase measurement is achieved with the ACE1 active electrode circuit which measures the amplitude and phase of the voltage and the applied current at the location at which current is injected into the body. An evaluation of the system performance under typical operating conditions includes details of demodulation and calibration and an in-depth look at insightful metrics, such as signal-to-noise ratio variations during a single current pattern. Static and dynamic images of conductivity and permittivity are presented from ACE1 data collected on tank phantoms and human subjects to illustrate the system's utility.

A real-time implementation of Calderón's method for the reconstruction of a 2-D conductivity from electrical impedance tomography data is presented, in which domain-specific modeling is taken into account. This is the first implementation of Calderón's method that accounts for correct modeling of non-symmetric domain boundaries in image reconstruction. The domain-specific Calderón's method is derived and reconstructions from experimental tank data are presented, quantifying the distortion when correct modeling is not included in the reconstruction algorithm. Reconstructions from human subject volunteers are presented, demonstrating the method's effectiveness for imaging changes due to ventilation and perfusion in the human thorax.

The strong correlation between the CVs for tidal breathing, FEV1, and FVC, and the statistically significant ability of CV for tidal breathing to distinguish between healthy subjects and CF patients, and between the studied CF disease states suggests that the CV may be useful for measuring the extent and severity of structural lung disease.