Risk factors for CLABSI in pediatric cancer patients with a TIVAP may be related to the severity of the child's condition at catheter insertion. Insertion of the catheter before chemotherapy and unfavorable conditions such as malnutrition and bone marrow aplasia can increase the risk of CLABSI. Protocols must be revised and surveillance increased over the first 10 weeks of treatment.

Bone marrow necrosis (BMN) is an entity resulting from an infarction of the bone marrow stroma without involvement of the cortical bone. It is a serious complication which is associated with malignant neoplasia(among other diseases), with acute leukemia being the most described cause. From these cases, about 18% are acute lymphoblastic leukemia (ALL), affecting less than 0.5% of patients with this pathology. Its histopathology is marked by the depletion of fat cells in an eosinophilic medium with the presence of amorphous material in at least 50% of the sample. The presence of BMNs in acute leukemia suggests a worse prognosis and lower remission rates. This observational study describes a case report of BMN caused by acute leukemia, with the databeing obtained from the electronic medical record in the UNIVASF University Hospital System (UH).

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