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Elsevier Lago, MA.; Rupérez Moreno, MJ.; Martínez Martínez, F.; Monserrat Aranda, C.; Larra, E.; Gueell, JL.; Peris-Martinez, C. (2015). A new methodology for the in vivo estimation of the elastic constants that characterize the patient-specific biomechanical behavior of the human cornea. Journal of Biomechanics. 48(1): 38-43. doi:10.1016/j.jbiomech.2014.11.009. A new methodology for the in-vivo estimation of the elastic constants that characterize the patient-specific biomechanical behavior of the human cornea AbstractThis work presents a methodology for the in-vivo characterization of the complete biomechanical behavior of the human cornea of each patient. Specifically, the elastic constants of a hyperelastic, second-order Ogden model were estimated for 24 corneas corresponding to 12 patients. The finite element method was applied to simulate the deformation of human corneas due to non-contact tonometry, and an iterative search controlled by a genetic heuristic was used to estimate the elastic parameters that most closely approximates the simulated deformation to the real one. The results from a synthetic experiment showed that these parameters can be estimated with an error of about 5%. The results of 24 in-vivo corneas showed an overlap of about 90% between simulation and real deformed cornea and a modified Hausdorff distance of 25µm, which indicates the great accuracy of the proposed methodology.

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Elsevier Lago, MA.; Rupérez Moreno, MJ.; Martínez Martínez, F.; Monserrat Aranda, C.; Larra, E.; Gueell, JL.; Peris-Martinez, C. (2015). A new methodology for the in vivo estimation of the elastic constants that characterize the patient-specific biomechanical behavior of the human cornea. Journal of Biomechanics. 48(1): 38-43. doi:10.1016/j.jbiomech.2014.11.009. A new methodology for the in-vivo estimation of the elastic constants that characterize the patient-specific biomechanical behavior of the human cornea AbstractThis work presents a methodology for the in-vivo characterization of the complete biomechanical behavior of the human cornea of each patient. Specifically, the elastic constants of a hyperelastic, second-order Ogden model were estimated for 24 corneas corresponding to 12 patients. The finite element method was applied to simulate the deformation of human corneas due to non-contact tonometry, and an iterative search controlled by a genetic heuristic was used to estimate the elastic parameters that most closely approximates the simulated deformation to the real one. The results from a synthetic experiment showed that these parameters can be estimated with an error of about 5%. The results of 24 in-vivo corneas showed an overlap of about 90% between simulation and real deformed cornea and a modified Hausdorff distance of 25µm, which indicates the great accuracy of the proposed methodology.