Twenty one patients in a residential rehabilitation program fulfilling International Classification of Diseases-10 (ICD) criteria for alcohol dependence syndrome were recruited. On neuropsychological tests, alcohol dependent patients relapsed early if they made choices governed by immediate gain irrespective of later outcome, which is consistent with dysfunctional ventromedial-prefrontal cortex mediating the inability to resist the impulse to drink despite ultimately deleterious effects. The authors suggest that the use of neuropsychological tasks of decision making may have several advantages over more conventional strategies for studying alcoholism.

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The conventional antipsychotic drugs are associated with a wide range of unwanted effects (Barnes & Guy Edwards, 1993; Guy Edwards & Barnes, 1993). These side-effects represent part of the burden of patients given antipsychotic medication, affect compliance with treatment, and contribute to the prescribing clinician's weigh-ing-up of the risks and benefits of a particular antipsychotic in an individual case. The conventional drugs show differences in their side-effect profiles, particularly with regard to sedation and extrapyramidal problems, and it is probably a reasonable generalisation to state that these have largely governed clinicians' choice. The newer ‘atypical’ antipsychotics (such as clozapine, risperidone, sertindole, olanzapine, quetiapine and amisulpride) are less liable to cause extrapyramidal symptoms than the conventional antipsychotics. However, this advantage is greater for some of the new drugs than for others, and their safety profiles also differ in other key respects. Thus, in terms of side-effects and safety, each of these newer drugs must be evaluated individually.

Section 136 of the 1983 Mental Health Act empowers the police to detain those suspected of being mentally ill in public places. The current study is a retrospective analysis of those occurring within Westminster, London, over a six-month period. A high rate of referral was found. In those individuals assessed, schizophrenia was the commonest diagnosis, but personality disorder provided the largest number of assessments. This was due to the propensity of the latter individuals to present on multiple occasions. Those with personality disorders were significantly less likely to be placed under further sections of the Mental Health Act, less likely to be admitted to hospital and more likely to re-present under a further section 136. The inability of the current system to address these individuals' needs is a cause for concern.

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