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The diagnostic significance of the CD3 and Bcl-2 markers for determining the stage of acute intestinal failure was investigated. The authors used their own model. Loperamide at a dose of 0.09 mg/kg/day was used as a drug inducing intestinal failure. The study was carried out on 36 male Wistar rats weighing 250±30 g, comparable in age. The study groups included 12 animals. The length of the villi, the width of the villi, the depth of the crypts, and the width of the crypts were examined morphometrically. An UltraVision Quanto Detection System HRP Polymer (ThermoFisher, USA) was used as a detection system. In group I, there were pronounced inflammation in the form of lymphoplasmacytic infiltration, shortening and thinning of intestinal villi. The number of CD3+ cells, which were located mainly in the center of the upper part of the villi, increased significantly. Bcl-2 expression decreased. In group II, shortening and thinning of intestinal villi progressed. Paneth's cells disappeared. There was a significant decrease in CD3 + and almost complete absence of Bcl-2+ cells (p≤0.05). Thus, in this work, the dynamics of the expression of pro-inflammatory and anti-apoptotic markers and their relationship with a complex of morphological changes in the wall of the small intestine of rats during the modeling of acute enteric failure have been established.

The diagnostic significance for levels of alkaline phosphatase (ALP) and intestinal alkaline phosphatase (IAP) and their ratio in blood serum and intestinal contents were compared to assess the degree of acute enteral insufficiency in urgent surgical pathology complicated by peritonitis. The results of examination of 112 patients with acute surgical pathology complicated by peritonitis were retrospectively analyzed. Biochemical data were compared with clinical and instrumental data obtained by ultrasonography and Doppler flowmetry. The main statistical indicator was Spearman's rank correlation coefficient, which showed a moderate direct correlation in patients with stage I and II enteral insufficiency (r=0.63 at p≤0.05), and in the group with st. III it showed a direct correlation with a high closeness of association (r=0.71 at p≤0.05). The IAP/ALP ratio makes it possible to objectively assess the severity of acute intestinal failure in urgent surgery

A b s t r A c t -The purpose of the research work was to study the mechanical properties of a de-epithelized skin graft and polypropylene mesh prosthesis used in herniology. Tensometric studies included: tensile strength and bursting strength of suture material. The average value of tensile load of the skin graft is 51,2±4,1 N/cm 2 , of a synthetic implant -19,9±3,4 N/cm 2 . It was noted, however, that the compliance of the skin graft is higher than that of the mesh implant. The average value of the bursting strength of the skin graft by suture material is 20,1±2,7 N/cm 2 . The skin graft, while maintaining anisotropy during tensometric studies, showed the ability of compliance and tensile strength more than 2 times higher, and the bursting strength 1,4 times higher than the polypropylene implant. K e y w o r d s -ventral hernia; mesh implant; autodermal transplant; tensometry.

О страя кишечная непроходимость выявляется у 5 заболевших на 100 тысяч человек, определяя от 3 до 5 % госпитализации в хирургические стационары. Летальность при дан-ной патологии остаётся высокой и, по данным разных авторов, колеблется от 5,1 до 8,4 %, занимая одно из ведущих мест среди всех ургентных хирургических заболеваний. Послеоперацион