A facile and direct protocol to determine the absolute configurations of chiral mono-alcohols without analyte derivatization can now be realized using a novel circular dichroic (CD)-sensitive bis(zinc porphyrin) BP1 host system. The binding of mono-alcohols to BP1 should be greatly enhanced by the simultaneous double coordination of the hydroxyl group to the two central metals of the porphyrin subunits.

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Porphyrin derivatives R 0130 A Facile and Efficient Synthesis of Mono-and Bis-Functionalized meso-Substituted Porphyrins via Palladium-Catalyzed NegishiCross-Coupling. -(TAKANAMI*, T.; YOTSUKURA, M.; INOUE, W.; INOUE, N.; HINO, F.; SUDA, K.; Heterocycles 76 (2008) 1, 439-453; Meiji Pharm. Univ., Kiyose, Tokyo 204, Japan; Eng.) -R. Staver 09-110