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Serum LDH isoenzyme fractions were evaluated in non‐diabetic control subjects, diet‐controlled diabetic patients and diabetic patients receiving chlorpropamide (Diabinese) in addition to diet. Statistically significant elevations of fraction I were observed in both the diet‐controlled and the chlorpropamide diet‐controlled diabetic groups when compared with the normal controls. Fraction III, however, showed a statistically significant decrease in activity in the two diabetic groups when compared with the normal controls. No significant changes were observed in the other fractions. The findings indicate that the diabetic state per se may elicit an increase in fraction I with a decrease in fraction III, and that chlorpropamide therapy has no effect on the relative concentrations of the various serum LDH isoenzymes. This evidence confirms a previous observation from this laboratory that liver function remains unaltered during chlorpropamide therapy and that the mild abnormalities reported here are in all likelihood peculiar to the diabetic state itself.

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