In many organisms, cytochrome P450 enzymes are the primary detoxifying enzymes. Enhanced P450 activity can be mediated by the emergence of new genes, increased transcription due to mutations in the promoter regions, changes in enzyme structures and functions due to mutations in protein-coding regions, or changes in post-translational modifications; all of these changes are subject to insecticide selection pressure. Multiple signalling pathways and key effector molecules are involved in the regulation of insect P450s. Increased P450 activity is a key mechanism inducing insect resistance. Hence, downregulation of selected P450s is a promising strategy to overcome this resistance. Insect P450 inhibitors that act as insecticide synergists, RNA interference to induce P450 gene silencing, and the use of transgenic insects and crops are examples of strategies utilized to overcome resistance. This article reviews the latest advances in studies related to insect P450s-mediated agrochemical resistance, with focuses on the regulatory mechanisms and associated pest management strategies. Future investigations on the comprehensive regulatory pathways of P450-mediated detoxification, identification of key effectors, and downregulation strategies for P450s will ecologically, economically, and practically improve pest management.

Volatile organic compounds (VOCs) can have an important influence on plant-insect interactions. In particular, insect behaviors are often influenced by the volatiles of both host plants and non-host plants. The objective of this study was to assess the behavioral responses of the tobacco aphid, Myzus persicae to the volatiles of Lavandula angustifolia (Lamiaceae). Our studies using a range doses of plants have shown that, When the mass of L. angustifolia was more than or equal to 4.0 g, volatiles emitted from plants showed repellent effects on M. persicae, but at masses of less than 4.0 g, M. persicae did not exhibit significantly preference. These findings provide new insights into the interactions between L. angustifolia plants and M. persicae, which will contribute to the development of new management strategies for biological control of insect pests.

Essential oils can have an impact on behavioural responses of cigarette beetle (Lasioderma serricorne). In this study, we provide evidence that some chemical compounds in essential oil of tobacco (Nicotiana tabacum) leaves, which were subjected to hydrodistillation and extracted with n-hexane, can strongly attract L. serricorne significantly. Two main chemical constituents, 6, 8-nonadien-2-one, 8-ethyl-5 -(1-methylethyl) and 1-(2, 6, 6-trimethyl-1, 3-cyclohexadien-1-yl) 2 -buten-1-one, in the essential oils were confirmed by GC-MS analysis. This result could be helpful to find some chemical compositions from N. tabacum as leading compounds for development of new bionic attractant.