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Purpose The primary aim of this study was to report the early clinical and radiographic outcomes of patients who have been treated with total knee arthroplasty (TKA) using the Persona knee system. The secondary aim was to compare patient‐reported outcomes (PROs) of the Persona knee system to those of the NexGen implant. Methods A registry‐based study of a consecutive series of 112 patients (129 knees) treated with the Persona knee system from a single center was conducted. Preoperative, 1‐year, and 2‐year radiographs and PROs were analyzed. Postoperative radiographs were assessed for radiolucency and component positioning. Patients were monitored for postoperative complications and revision. Two‐year PROs were compared to a 1:1 propensity score‐matched cohort of patients treated with the NexGen knee system. Results Ninety‐five percent of knees were within literature‐defined safe ranges of the anatomical tibiofemoral axis, tibial varus/valgus angle, femoral flexion/extension angle, and tibial slope. Radiolucency was observed in 0.9% and 1.3% of knees at one and 2 years, respectively. Two‐year PRO values demonstrated clinically meaningful improvements from the preoperative values. The cumulative 2‐year percent revision was 3.0% (95% confidence interval 1.9–3.8%); there were no revisions due to implant mechanical failure. Patients treated with the Persona knee system had higher KOOS symptom (p = 0.037) and KOOS QOL (p < 0.001) scores compared to patients with the NexGen knee system. Conclusions This knee design demonstrates excellent clinical outcomes, similar or better than the NexGen knee system, at early follow‐up. Level of evidence III.

For patients undergoing orthopaedic surgery, preoperative risk modification and control of comorbidities can maximize safety and improve outcomes. Anemia is common among orthopaedic patients, and its prevalence increases with patient age. Although surgeons are well versed in intraoperative blood conservation, preoperative anemia treatment is often deferred to primary care physicians, who may not understand the importance of a thorough assessment and treatment. Orthopaedic surgeons should understand the causes and treatments of anemia to advocate that patients receive appropriate preoperative care. Mean corpuscular volume and reticulocyte count can help determine the cause of anemia and assess the bone marrow's ability to produce red blood cells. These values can be used to aid in diagnosis and treatment plans. Iron deficiency anemia, the most common type, is a microcytic anemia easily treated with iron supplementation. In cases of trauma, anemia can be related to acute blood loss and underlying conditions. Fracture patterns and preexisting comorbidities should be assessed. The role of intravenous iron supplementation in this setting has not been clearly shown. Patients needing urgent procedures that might involve substantial blood loss should receive transfusions if they have hemoglobin levels <8 g/dL or symptomatic anemia.