Humic acids (HAs) are natural polymers with diverse functional groups that have been documented and utilized in traditional Chinese medicine. Dextran sulfate sodium (DSS)-induced colitis has been used as a model to study inflammatory bowel disease. In this research, we investigate the effect of HAs on ameliorating DSS-induced colitis in mice. Our aim here was to investigate if HAs could be a remedy against colitis and the mechanisms involved. The results show that HAs facilitated a regain of body weight and restoration of intestinal morphology after DSS-induced colitis. HAs treatment alters the community of gut microbiota with more Lactobacillus and Bifidobacterium. Changes in bacterial community result in lower amounts of lipopolysaccharides in mouse sera, as well as lower levels of inflammatory cytokines through the Toll-like receptor 4 (TLR4)-NF-κB pathway. HAs also promoted the expression of tight junction proteins, which protect the intestinal barrier from DSS damage. Cell experiments show that HAs display an inhibitory effect on DSS growth as well. These results suggest that HAs can alleviate colitis by regulating intestinal microbiota, reducing inflammation, maintaining mucosal barriers, and inhibiting pathogen growth. Thus, HAs offer great potential for the prevention and treatment of colitis.

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With the increasing number of university graduates in our country, the employment pressure of university graduates is increasing continuously. It is necessary and significant for the improvement of university students' innovation and entrepreneurial practice ability. Therefore, it is imperative to find out in a timely manner the problems that exist in this process and propose solutions to the problems.This paper analyzes the importance of improving college students' innovation and entrepreneurship and the problems in the improvement of college students' abilities in innovation and entrepreneurship practice. It also proposes strategies for upgrading the college students' creative entrepreneurial ability, that is, diversification of talent standards, breaking the constraints of traditional teaching models, optimizing teaching methods, strengthening practical teaching. In order to enhance the ability of college students to practice innovation and entrepreneurship, it will provide reference for colleges and universities to cultivate innovative entrepreneurial talents. The Importance and Necessity of Promoting College Students' Innovation and Entrepreneurship Cultivating College Students' Ability of Innovation and Entrepreneurship is Conducive to the Development of the Socialist Market Economy. Since the reform and opening up policy was implemented for almost 40 years, China's socialist market economy has achieved rapid development and more market vitality is needed. Under the new normal economy, the socialist market economy in our country needs to inject fresh vitality. As the pride of the times, college