In Mexico, corn is the most widely used cereal, however, in arid areas it is not possible to cultivate it, so white sorghum represents an alternative. However, it is important to know the varieties nutritional content. Therefore, this study the proximal profile and fatty acids of six white sorghum varieties grown in Mexico were evaluated. Proximate analysis was carried out based on AACC methods and gas chromatography had been used for fatty acid analysis. Mazatlan and Sureño varieties showed the highest content of proteins (12%), fiber (7%), and ash (1.65%); regarding fat content, the highest values were found in Mazatlan and Costeño (4%). For fatty acid profile, saturated and unsaturated fatty acids were detected, including Omega 6 and 9. Sorghum represents an alternative, specially for arid and semiarid regions. The results indicate that these varieties are a viable source to produce foods for human consumption.