The diagnosis of trichotillomania (TT) is often difficult as it presents similar clinical manifestations with other hair loss diseases, especially alopecia areata (AA). As TT often coexists with AA, the methodology enabling reliable detection of TT in AA needs to be developed. Recently, characteristic dermoscopic findings of TT have been reported, yet, they were most clearly detectable by conventional immersion dermoscopy, not by dry dermoscopy, a technique more easily adoptable in daily practice. In addition, the usefulness of those signs for differentiating TT from AA has not been sufficiently assessed. Through intensive scanning of hair loss lesions by dry dermoscopy in AA patients with TT, we found a sign potentially useful for detecting hidden TT. The sign we named "follicular microhemorrhage" (FMH) represents a red dot corresponding to a follicular ostia capped or stuffed with blood clot and suggests a history of traumatic forced plucking. So far, we have detected FMH in four TT patients with moderate to severe AA. Although further accumulation of cases is necessary, FMH would be beneficial to dissect complicated pathophysiology of hair loss in AA patients with TT.
IgG4-related disease (IgG4-RD) is a newly recognized condition that is characterized by raised levels of serum IgG4, tissue infiltration of IgG4-positive plasma cells and presence of fibrosis. It affects multiple organs, including the pancreas, bile duct, and lacrimal and salivary glands. Skin lesions have rarely been reported, and those that have were described as distributed mainly in the head and neck region. We report a case of IgG4-RD with autoimmune pancreatitis and skin lesions on the trunk and limbs. The skin lesions responded well to oral prednisolone (PSL); however, tapering of PSL to 5 mg/day resulted in recurrence. At present, the skin disease is well controlled at a dose of 7 mg/day. Interestingly, IgG4 levels fluctuated with changes in the PSL dose but did not coincide with the severity of the skin disease, implying that the raised levels of IgG4 did not directly influence the skin symptoms.
REFERENCES1 Urquhart JL, Uzieblo A, Kohler S. Detection in HHV-8 in pyogenic granuloma-like Kaposi sarcoma. Am J Dermatopathol 2006; 28: 317-321. 2 Ryan P, Aarons S, Murray D et al. Human herpes virus 8(HHV-8) detected in two patients with Kaposi's sarcoma-like pyogenic granuloma. J Clin Pathol 2002; 55: 619-622. 3 Cabibi D, Cacciartore M, Viviano E, Guarnotta C, Aragona F. 'Pyogenic granuloma-like Kaposi's sarcoma' on the hands: immunohistochemistry and human herpesvirus-8 detection. J Eur Acad Dermatol Venereol 2009; 23: 587-589. 4 Kim HJ, Kim JY, Choi JE, Kye YC, Ahn HH, Seo SH. A firm, bluish, hemorrhagic nodule on the left heel. Int J Dermatol 2013; 52: 131-132. 5 Lee DY, Park SW. Kaposi sarcoma mimicking pyogenic granuloma below the toenail. Int J Dermatol 2014; 53: e202-e204.
Acral lentiginous melanoma (ALM) of the sole sometimes has a hyperkeratotic appearance and mimics a pigmented wart. We report a case of an 81-year-old woman with an ALM on the left sole with hyperkeratosis. Due to its presentation it was difficult to make a correct diagnosis at the beginning. Finally we noticed several small, pigmented macules around the wart-like lesion with the parallel ridge pattern on dermoscopy, strongly suggesting acral melanoma. When a hyperkeratotic pigmented lesion on the sole is encountered, one should rule out melanoma by careful examination of the periphery of the lesion. Dermoscopy is a helpful adjunct for the diagnosis of an unusual case like this.
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