Skin lesions in a patient with IgG4-related disease

Ise, Misaki; Yasuda, Fumiyo; Suzaki, Reiko; Kurihara, Shuichi; Konohana, Izumi

doi:10.1111/ced.12372

Cited by 12 publications

(7 citation statements)

References 10 publications

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“…h,i,j). These histopathological findings and clinical symptoms in the present case were similar to previously reported skin lesions involved in IgG4‐RD . As the skin lesions in the present case are not prominent, they might be a manifestation of conditions other than IgG4‐RD.…”

Section: Discussionsupporting

confidence: 90%

IgG4‐related disease manifesting the gastric wall thickening

Kawano

Ishii

Kimura

et al. 2015

Pathology International

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IgG4-related disease (IgG4-RD) is a recently designated disease entity and its full picture has not yet been elucidated. Here, we report an unusual case of a patient with gastric wall thickening secondary to IgG4-RD. A 68-year-old male visited our hospital with itchy skin lesions and an episode of organizing pneumonia. On the suspicion of malignancy-associated skin lesions, computed tomography (CT) was performed. The CT revealed prominent thickening of the gastric wall. Due to the possibility of malignancy, the patient underwent distal gastrectomy. Histopathological examination showed fibrosis of the submucosa and prominent thickening of the muscularis propria. Most of infiltrating cells were IgG4-positive plasma cells. Post-operative blood test revealed significantly high serum levels of total IgG and IgG4. Based on these histological features, the patient was given a definitive diagnosis of IgG4-RD. Further accumulation of cases like the present case that develop IgG4-RD with rare manifestations would lead to the elucidation of pathogenesis.

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Section: Discussionsupporting

confidence: 90%

IgG4‐related disease manifesting the gastric wall thickening

Kawano

Ishii

Kimura

et al. 2015

Pathology International

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“…Many patients with IgG4-related skin symptoms are reported to be Asian middle-aged and older men. Some investigators have reported that skin lesions were unresponsive to topical corticosteroids (14,15). These features fit the present case.…”

Section: Discussionsupporting

confidence: 89%

Punctate Purpura Complicated with Immunoglobulin G4-related Disease

et al. 2021

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Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition affecting multiple organs; however, the involvement of skin lesions is rare. We herein report a 65-year-old man who presented with pruritic punctate purpura on both legs and elevated liver enzyme levels. Computed tomography showed enlargement of the pancreas and thickening of the bile duct wall. Magnetic resonance cholangiopancreatography showed diffuse irregular constriction of the main pancreatic duct, stricture of the lower common bile duct, and dilation after confluent stricture. A histopathologic examination of the pancreas and his enlarged salivary gland showed infiltration of IgG4-positive plasma cells. Ultimately, the patient was diagnosed with IgG4-RD.

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“…Conversely, some cases have appeared to involve only a single organ disorder as IgG4-RD. Some cases have been reported to involve organs not typically associated with IgG4-RD, such as the heart (a lesion caused complete atrioventricular block [ 8 ]), skin [ 9 ], superior vena cava [ 10 ], hard palate [ 11 ], small intestine [ 12 ], esophagus [ 13 ], and colon [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Immunoglobulin G4-Related Disease with Extensive Multiorgan Involvements

Higashioka

Yoshida

Oryoji

et al. 2015

Case Reports in Rheumatology

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We report a case of IgG4-related disease (IgG4-RD) with multiple ten-organ involvement. This case showed many clinical findings, such as bilateral swelling of salivary and lacrimal glands, autoimmune pancreatitis, interstitial nephritis, retroperitoneal fibrosis, periaortitis, systemic swelling of lymph nodes, pulmonary lesions, splenomegaly, and jejunal lesions. He was suspected as having SLE or malignant lymphoma but diagnosed as having IgG4-RD by the elevated serum IgG4 level and histological findings from kidney and lymph node. We report a case of IgG4-RD with multiple ten-organ involvement that was successfully treated with prednisolone therapy.

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Skin lesions in a patient with IgG4-related disease

Cited by 12 publications

References 10 publications

IgG4‐related disease manifesting the gastric wall thickening

IgG4‐related disease manifesting the gastric wall thickening

Punctate Purpura Complicated with Immunoglobulin G4-related Disease

A Case of Immunoglobulin G4-Related Disease with Extensive Multiorgan Involvements

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